2-METHYLTHIO-3,5-METHYLPYRAZINE

CAS NO.：67952-65-2
Empirical Formula: C7H10N2S
Molecular Weight: 154.23
MDL number: MFCD00014610
EINECS: 267-918-3
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 01:11:55

What is 2-METHYLTHIO-3,5-METHYLPYRAZINE?

Description

2-Methyl-(3 or 5 or 6)-(methylthio)pyrazine (mixture of isomers) is like roasted almonds, hazelnuts. This may be prepared from 2-methylchloropyrazine; a mixture of 2-methyl-3-methylthiopyrazine, 2-methyl-5-methylthiopyrazine, and 2-methyl-6-methylthiopyrazine is obtained.

Chemical properties

2-Methyl-3(or 5 or 6)-methylthiopyrazine has a roasted almond, hazelnut and vegetable aroma.

Preparation

From 2-methylchloropyrazine; a mixture of 2-methyl-3-methylthiopyrazine, 2-methyl-5-methylthiopyrazine, and 2-methyl-6-methylthiopyrazine is obtained.

Aroma threshold values

Detection: 4 to 60 ppb. Aroma characteristics at 1.0%: toasted popcorn, roasted almond, hazelnut, peanut and cashewnutty, with a caramellic and corn-chip nuance.

Taste threshold values

Taste characteristics at 3 to 10 ppm: nutty, roasted and earthy with coffee and corn nuances, peanut and pecan nutty, popcorn and corn chip–like with a burnt musty nuance.

Properties of 2-METHYLTHIO-3,5-METHYLPYRAZINE

Density	1.145 g/mL at 25 °C(lit.)
refractive index	n20/D 1.583(lit.)
FEMA	3208 \| (METHYLTHIO)METHYLPYRAZINE (MIXTURE OF ISOMERS)
Flash point:	193 °F
Odor	at 0.10 % in dipropylene glycol. nutty earthy peanut musty coffee vegetable
JECFA Number	797
CAS DataBase Reference	67952-65-2(CAS DataBase Reference)
EPA Substance Registry System	Pyrazine, methyl(methylthio)- (67952-65-2)

Safety information for 2-METHYLTHIO-3,5-METHYLPYRAZINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.