2-Methylbenzyl chloride
Synonym(s):α-Chloro-o-xylene
- CAS NO.：552-45-4
- Empirical Formula: C8H9Cl
- Molecular Weight: 140.61
- MDL number: MFCD00000899
- EINECS: 209-013-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:23:57
What is 2-Methylbenzyl chloride?
Chemical properties
Colorless to light yellow liqui
The Uses of 2-Methylbenzyl chloride
o-Chloromethyltoluene is a building block that has been used in the preparation of fenarimol analogs showing curative activity in an experimental model of Chagas disease.
General Description
A colorless to pale-yellow colored liquid with a pungent odor. Insoluble in water. Slightly denser than water. Flash point 165°F. Contact may irritate skin, eyes, and mucous membranes. May be toxic by ingestion. Used to make other chemicals.
Air & Water Reactions
Because of its insolubility 2-Methylbenzyl chloride doesn't react vigorously with water, although 2-Methylbenzyl chloride does generate annoying levels of hydrogen chloride fumes.
Reactivity Profile
2-Methylbenzyl chloride is rapidly decomposed when heated in the presence of iron.
Health Hazard
Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Flammability and Explosibility
Not classified
Properties of 2-Methylbenzyl chloride
| Melting point: | -2 °C |
| Boiling point: | 197-199 °C(lit.) |
| Density | 1.063 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 165 °F |
| storage temp. | 2-8°C |
| solubility | soluble in Ether |
| form | Liquid |
| color | Clear colorless to light yellow |
| Merck | 14,10091 |
| BRN | 386016 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents, bases, alcohols, amines. Corrodes steel. |
| CAS DataBase Reference | 552-45-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzene, 1-(chloromethyl)-2-methyl-(552-45-4) |
| EPA Substance Registry System | o-(Chloromethyl)toluene (552-45-4) |
Safety information for 2-Methylbenzyl chloride
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H314:Skin corrosion/irritation H411:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Methylbenzyl chloride
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