2-Iodothiophene
- CAS NO.：3437-95-4
- Empirical Formula: C4H3IS
- Molecular Weight: 210.04
- MDL number: MFCD00005424
- EINECS: 222-342-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:19:24
What is 2-Iodothiophene?
Chemical properties
colorless to light yellow liquid
The Uses of 2-Iodothiophene
2-Iodothiophene was used in the synthesis of (E)-and (Z)-2,3-difluoro-3-aryl substituted acrylic esters. It was also used as monomer in the preparation of thin conductive films via plasma polymerization of 2-iodothiophene.
Synthesis Reference(s)
Tetrahedron Letters, 36, p. 4883, 1995 DOI: 10.1016/0040-4039(95)00876-E
General Description
Mechanism of the fluoride-free, palladium-catalyzed cross-coupling reaction of 2-iodothiophene with potassium (E)-heptenyldimethylsilanolate has been investigated. 2-Iodothiophene participates in microwave-enhanced, rapid homogeneous-phase version of the Sonogashira reaction.
Properties of 2-Iodothiophene
| Melting point: | -40 °C (lit.) |
| Boiling point: | 73 °C/15 mmHg (lit.) |
| Density | 1.902 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 160 °F |
| storage temp. | 2-8°C |
| form | Liquid |
| color | Clear yellow-green to red-brown |
| Specific Gravity | 1.902 |
| Sensitive | Light Sensitive |
| BRN | 104666 |
| CAS DataBase Reference | 3437-95-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Thiophene, 2-iodo-(3437-95-4) |
| EPA Substance Registry System | Thiophene, 2-iodo- (3437-95-4) |
Safety information for 2-Iodothiophene
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Iodothiophene
| InChIKey | ROIMNSWDOJCBFR-UHFFFAOYSA-N |
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