Cephalothin sodium
Synonym(s):7-(2-Thienylacetamido)cephalosporanic acid sodium salt;Cephalothin sodium salt;Cephalotin sodium salt
- CAS NO.:58-71-9
- Empirical Formula: C16H16N2O6S2.Na
- Molecular Weight: 418.42
- MDL number: MFCD00072025
- EINECS: 200-394-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-26 14:50:00
What is Cephalothin sodium?
Description
Cefalothin is a β-lactam cephalosporin antibiotic. It inhibits the growth of various Gram-positive and Gram-negative bacteria, including several strains of S. pyogenes, S. aureus, C. tetani, N. gonorrhoeae, Salmonella, and Shigella (MICs = 0.1-0.2, 0.312-0.625, 0.078, 1.25, 1.56-6.25, and 3.12-12.5 μg/ml, respectively). Cefalothin binds to E. coli penicillin-binding proteins (PBPs; IC50s = <0.25, 16, 37, and 1 μg/ml for PBP1a, 1bs, 2, and 3, respectively, in a radioligand binding assay), which interferes with bacterial morphogenesis. It exhibits antibacterial activity in mouse models of infection with S. pyogenes, D. pneumoniae, and S. aureus. Formulations containing cefalothin were previously used in the prophylaxis and treatment of bacterial infections.
The Uses of Cephalothin sodium
Cephalothin sodium salt is used to study the mechanism of liposome encapsulated antibiotics1, strategies for co-opting β-lactamases of Gram-negative bacteria for treatment of antibiotics2, and for immunology studies in relation to antibiotics.3 It is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP6 on bacterial cell wall mucopeptide synthesis.
What are the applications of Application
Cephalothin sodium salt is a firrst generation cephem antibiotic
Properties of Cephalothin sodium
Melting point: | 240°C |
storage temp. | Inert atmosphere,2-8°C |
solubility | H2O: 50 mg/mL, clear, faintly yellow |
form | neat |
color | White to Off-White |
Water Solubility | 158 mg/L |
Safety information for Cephalothin sodium
Signal word | Danger |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H317:Sensitisation, Skin H334:Sensitisation, respiratory |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P284:Wear respiratory protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P342+P311:IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
Computed Descriptors for Cephalothin sodium
Abamectin manufacturer
GLP Pharma Standards
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