2-HYDROXY-5-NITROBENZYL BROMIDE
Synonym(s):α-Bromo-4-nitro-o-cresol;2-Bromomethyl-4-nitrophenol;Koshland I;Koshland’s Reagent I
- CAS NO.：772-33-8
- Empirical Formula: C7H6BrNO3
- Molecular Weight: 232.03
- MDL number: MFCD00007340
- EINECS: 212-248-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:21:08
What is 2-HYDROXY-5-NITROBENZYL BROMIDE?
Chemical properties
Beige to yellow crystalline powder
The Uses of 2-HYDROXY-5-NITROBENZYL BROMIDE
2-Hydroxy-5-nitrobenzyl bromide is a chemical reagent that reacts with and modifies chemically the tryptophan portion of protein molecules..
The Uses of 2-HYDROXY-5-NITROBENZYL BROMIDE
Reagent for sulfhydryl modification.1
The Uses of 2-HYDROXY-5-NITROBENZYL BROMIDE
2-Hydroxy-5-nitrobenzyl bromide was used in covalent modification of tryptophan and tryptophan residues in monoclonal immunoglobulin. It was also used as reagent for sulfhydryl modification
What are the applications of Application
2-Hydroxy-5-nitrobenzyl bromide is A chemical reagent that reacts with and modifies chemically the tryptophan portion of protein molecules.
Synthesis Reference(s)
Journal of the American Chemical Society, 86, p. 1448, 1964 DOI: 10.1021/ja01061a045
General Description
2-Hydroxy-5-nitrobenzyl bromide is a protein modifying reagent.
Purification Methods
Crystallise the bromide from *benzene or *benzene/ligroin. It is slightly soluble in EtOH, soluble in *C6H6 and AcOH, and very soluble in ligroin. [Beilstein 6 H 367.]
Properties of 2-HYDROXY-5-NITROBENZYL BROMIDE
| Melting point: | 144-149 °C(lit.) |
| Boiling point: | 383.0±32.0 °C(Predicted) |
| Density | 1.795 |
| refractive index | 1.6090 (estimate) |
| storage temp. | 2-8°C |
| solubility | chloroform: soluble25mg/mL, clear, yellow |
| pka | 6.16±0.30(Predicted) |
| form | Crystalline Powder |
| color | Beige to light brown |
| BRN | 1868798 |
| CAS DataBase Reference | 772-33-8(CAS DataBase Reference) |
| EPA Substance Registry System | Phenol, 2-(bromomethyl)-4-nitro- (772-33-8) |
Safety information for 2-HYDROXY-5-NITROBENZYL BROMIDE
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-HYDROXY-5-NITROBENZYL BROMIDE
2-HYDROXY-5-NITROBENZYL BROMIDE manufacturer
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product: 772-33-8 2-Hydroxy-5-nitro benzyl bromide 98%
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