2-HYDROXY-5-NITROBENZYL BROMIDE
Synonym(s):α-Bromo-4-nitro-o-cresol;2-Bromomethyl-4-nitrophenol;Koshland I;Koshland’s Reagent I
- CAS NO.：772-33-8
- Empirical Formula: C7H6BrNO3
- Molecular Weight: 232.03
- MDL number: MFCD00007340
- EINECS: 212-248-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-06-04 16:00:12
What is 2-HYDROXY-5-NITROBENZYL BROMIDE?
Chemical properties
Beige to yellow crystalline powder
The Uses of 2-HYDROXY-5-NITROBENZYL BROMIDE
Reagent for sulfhydryl modification.1
The Uses of 2-HYDROXY-5-NITROBENZYL BROMIDE
2-Hydroxy-5-nitrobenzyl bromide is a chemical reagent that reacts with and modifies chemically the tryptophan portion of protein molecules..
The Uses of 2-HYDROXY-5-NITROBENZYL BROMIDE
2-Hydroxy-5-nitrobenzyl bromide was used in covalent modification of tryptophan and tryptophan residues in monoclonal immunoglobulin. It was also used as reagent for sulfhydryl modification
What are the applications of Application
2-Hydroxy-5-nitrobenzyl bromide is A chemical reagent that reacts with and modifies chemically the tryptophan portion of protein molecules.
Synthesis Reference(s)
Journal of the American Chemical Society, 86, p. 1448, 1964 DOI: 10.1021/ja01061a045
General Description
2-Hydroxy-5-nitrobenzyl bromide is a protein modifying reagent.
Purification Methods
Crystallise the bromide from *benzene or *benzene/ligroin. It is slightly soluble in EtOH, soluble in *C6H6 and AcOH, and very soluble in ligroin. [Beilstein 6 H 367.]
Properties of 2-HYDROXY-5-NITROBENZYL BROMIDE
| Melting point: | 144-149 °C(lit.) |
| Boiling point: | 383.0±32.0 °C(Predicted) |
| Density | 1.795 |
| refractive index | 1.6090 (estimate) |
| storage temp. | 2-8°C |
| solubility | chloroform: soluble25mg/mL, clear, yellow |
| pka | 6.16±0.30(Predicted) |
| form | Crystalline Powder |
| color | Beige to light brown |
| BRN | 1868798 |
| CAS DataBase Reference | 772-33-8(CAS DataBase Reference) |
| EPA Substance Registry System | Phenol, 2-(bromomethyl)-4-nitro- (772-33-8) |
Safety information for 2-HYDROXY-5-NITROBENZYL BROMIDE
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-HYDROXY-5-NITROBENZYL BROMIDE
New Products
2-Bromo-4-hydroxypyridine Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) Dibenzo[b,f][1,4]thiazepin-11(10H)-one 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One Cis-Tosylate 1-(4-methoxyphenyl)-4-(4-Nitrophenyl)Piperazine (IT-1) 2'-Fluoroacetophenone 1-aminocyclobutanecarbonitrile hydrochloride AMINO-O-TOLYL-ACETIC ACID N-Methyl-2-amino-2-methylpropionamide 4-(FMOC-AMINO)-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 1-Aminocyclobutanecarboxylic Acid Hydrochloride METHANOL-D1(OD) TERTIARY BUTANOL-D9 N-ETHYL-D5-AMINE HYDROCHLORIDE BENZOIC ACID-D CHLOROFORM-D TOLUENE-D3 2-(2-Bromophenyl)ethanol Boc-D-Glu(OMe)-OMe 2,5 Dibromopyridine Ethyl 4-hydroxy-3-oxobutanoate Dimethyl (2S)-2-((tert-butoxycarbonyl)amino)-4-(cyanomethyl)pentanedioate 1-(3-Chlorophenyl)piperazine hydrochlorideRelated products of tetrahydrofuran
You may like
-
772-33-8 2-Hydroxy-5-nitro benzyl bromide 98%View Details
772-33-8 -
772-33-8 98%View Details
772-33-8 -
772-33-8 98%View Details
772-33-8 -
2-Hydroxy-5-nitrobenzyl Bromide CAS 772-33-8View Details
772-33-8 -
2-Hydroxy-5-nitrobenzyl bromide CAS 772-33-8View Details
772-33-8 -
1-aminocyclobutanecarbonitrile hydrochloride 845821-84-3 98+View Details
845821-84-3 -
98071-16-0 1-Aminocyclobutanecarboxylic Acid Hydrochloride 98+View Details
98071-16-0 -
ADC-151View Details
27176-87-0
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.