2'-Hydroxy-5'-methoxyacetophenone
- CAS NO.：705-15-7
- Empirical Formula: C9H10O3
- Molecular Weight: 166.17
- MDL number: MFCD00008731
- EINECS: 211-882-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-06 19:22:19
What is 2'-Hydroxy-5'-methoxyacetophenone?
Chemical properties
yellow crystalline powder
The Uses of 2'-Hydroxy-5'-methoxyacetophenone
2′-Hydroxy-5′-methoxyacetophenone is observed as a side reaction product of elbs persulphate oxidation of phenols. 2-Hydroxy-5-methoxyacetophenone is also used to prepare substituted chromanone and chromone derivatives as sirtuin 2-selective inhibitors.
Preparation
reparation by reaction of dimethyl sulfate on 2,5-dihydroxyacetophenone, ? with potassium carbonate in acetone at r.t. (74%) ; ? with aqueous sodium hydroxide solution at reflux (35%).
What are the applications of Application
2'-Hydroxy-5'-methoxyacetophenone could find some use in perfume compositions, e. g., in artificial Oakmoss, in New Mown Hay fragrances, and in certain heavy florals. It blends well with Labdanum and with Lavender type oils, and it lends a certain amount of power and undertones to the fragrance.
Synthesis Reference(s)
Synthesis, p. 901, 1985 DOI: 10.1055/s-1985-31380
General Description
2′-Hydroxy-5′-methoxyacetophenone is observed as a side reaction product of elbs persulphate oxidation of phenols.
Properties of 2'-Hydroxy-5'-methoxyacetophenone
| Melting point: | 52 °C(lit.) |
| Boiling point: | 254.38°C (rough estimate) |
| Density | 1.1708 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| Flash point: | >230 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| pka | 10.65±0.18(Predicted) |
| form | Crystalline Powder |
| color | Yellow |
| Odor | Aromatic, somewhat medicinal, warm, woody -the herbaceous odour of good tenacity. |
| BRN | 1239364 |
| CAS DataBase Reference | 705-15-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethanone, 1-(2-hydroxy-5-methoxyphenyl)-(705-15-7) |
Safety information for 2'-Hydroxy-5'-methoxyacetophenone
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2'-Hydroxy-5'-methoxyacetophenone
| InChIKey | MLIBGOFSXXWRIY-UHFFFAOYSA-N |
2'-Hydroxy-5'-methoxyacetophenone manufacturer
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