2'-Methoxyacetophenone
Synonym(s):2-Acetylanisole
- CAS NO.：579-74-8
- Empirical Formula: C9H10O2
- Molecular Weight: 150.17
- MDL number: MFCD00008725
- EINECS: 209-446-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 02:17:03
What is 2'-Methoxyacetophenone?
Chemical properties
clear slightly yellow to orange or slightly
Chemical properties
Colorless to pale yellow clear liquid; powdery anisic almond phenolic aroma.
The Uses of 2'-Methoxyacetophenone
2''-Methoxyacetophenone is a useful building block, often used in the preparation of chalcones, such as the chalcones of 3-benzylidene-2-chlorocyclohex-1-enecarbaldehyde for use as potential anti-proliferative agents.
Preparation
Preparation by reaction of dimethyl sulfate with o-hydroxyacetophenone in the presence of sodium hydroxide.
Aroma threshold values
Anisic-type, medium strength odor; recommend smelling in a 1.00% solution or less.
Taste threshold values
Powdery musty anisic almond taste at 30 ppm in water.
Synthesis Reference(s)
Tetrahedron Letters, 22, p. 2605, 1981 DOI: 10.1016/S0040-4039(01)90532-5
Journal of the American Chemical Society, 72, p. 5161, 1950 DOI: 10.1021/ja01167a100
The Journal of Organic Chemistry, 52, p. 150, 1987 DOI: 10.1021/jo00377a027
Properties of 2'-Methoxyacetophenone
| Melting point: | 117–119°C |
| Boiling point: | 131 °C18 mm Hg(lit.) |
| Density | 1.09 g/mL at 25 °C(lit.) |
| refractive index | n |
| FEMA | 4163 | 2-METHOXYACETOPHENONE |
| Flash point: | 228 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Sparingly), Methanol (Sparingly) |
| form | Liquid |
| color | Clear slightly yellow to orange or slightly brown |
| Odor | at 1.00 % in propylene glycol. powdery anisic almond phenolic |
| Water Solubility | immiscible |
| Sensitive | Light Sensitive |
| JECFA Number | 2042 |
| BRN | 1100602 |
| CAS DataBase Reference | 579-74-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Ortho-methoxyacetophenone(579-74-8) |
| EPA Substance Registry System | Ethanone, 1-(2-methoxyphenyl)- (579-74-8) |
Safety information for 2'-Methoxyacetophenone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for 2'-Methoxyacetophenone
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