2-Fluoro-4-trifluoromethyl-pyridine
- CAS NO.：118078-66-3
- Empirical Formula: C6H3F4N
- Molecular Weight: 165.09
- MDL number: MFCD09879262
- EINECS: 687-071-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 02:16:58
What is 2-Fluoro-4-trifluoromethyl-pyridine?
The Uses of 2-Fluoro-4-trifluoromethyl-pyridine
Reactant for: Preparation of aminopyridines via amination reactions Catalytic ligand for: ? Regioselective preparation of tetramethylbiphenyls via aerobic oxidative coupling of xylene catalyzed by palladium
The Uses of 2-Fluoro-4-trifluoromethyl-pyridine
2-Fluoro-4-(trifluoromethyl)pyridine acts as a reactant in the preparation of aminopyridines through amination reactions. It is also used as a catalytic ligand for regioselective preparation of tetramethylbiphenyls through aerobic oxidative coupling of xylene catalyzed by palladium.
Properties of 2-Fluoro-4-trifluoromethyl-pyridine
| Boiling point: | 113℃ |
| Density | 1.355 g/mL at 25 °C |
| refractive index | n20/D1.400 |
| Flash point: | 23℃ |
| storage temp. | Refrigerated. |
| form | clear liquid |
| pka | -2.79±0.10(Predicted) |
| color | White to Yellow to Green |
| Water Solubility | Miscible with water, alcohol, acetonitrile and N,N-dimethylformamide |
Safety information for 2-Fluoro-4-trifluoromethyl-pyridine
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H226:Flammable liquids H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Fluoro-4-trifluoromethyl-pyridine
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