2-Fluoro-4-methylaniline
Synonym(s):2-Fluoro-p-toluidine
- CAS NO.：452-80-2
- Empirical Formula: C7H8FN
- Molecular Weight: 125.14
- MDL number: MFCD00040975
- EINECS: 610-237-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:27:03
What is 2-Fluoro-4-methylaniline?
Chemical properties
clear orange to orange-brown liquid
The Uses of 2-Fluoro-4-methylaniline
2-Fluoro-4-methylaniline is used in the preparation of 6-chloro-5-fluoroindole via Leimgruber-Batcho reaction. It is also used in the preparation of an (S)-amino alcohol, 2-amino-3-(2-fluoro-4-methylphenyl)-propan-1-ol.
The Uses of 2-Fluoro-4-methylaniline
2-Fluoro-4-methylaniline was used in the preparation of 6-chloro-5-fluoroindole via Leimgruber-Batcho reaction. It was also used in the preparation of an (S)-amino alcohol, 2-amino-3-(2-fluoro-4-methylphenyl)-propan-1-ol.
General Description
Rat liver microsomal metabolism of 2-fluoro-4-methylaniline was studied by HPLC.
Properties of 2-Fluoro-4-methylaniline
| Melting point: | 3 °C |
| Boiling point: | 70-71 °C/7 mmHg (lit.) |
| Density | 1.108 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 175 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | Liquid |
| pka | 3?+-.0.10(Predicted) |
| color | Clear orange to orange-brown |
| Water Solubility | Not miscible in water. |
| BRN | 2637578 |
| CAS DataBase Reference | 452-80-2(CAS DataBase Reference) |
Safety information for 2-Fluoro-4-methylaniline
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Fluoro-4-methylaniline
2-Fluoro-4-methylaniline manufacturer
GLR Innovations
Delhi
product: 2-Fluoro-4-Methylaniline CAS No 452-80-2, Grade Standard: Reagent Grade
New Products
2-(3-Methyl-1,2,4-oxadiazol-5-yl)acetic acid (as potassium salt) 2-fluoro-4-iodoaniline 4-Iodo-3,5-dimethylbenzonitrile Atorvastatin amide impurity/Atorvastatin EP Impurity F(Calcium Salt) Lantanoprost rc B Clidinium Bromide Impurity Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity N-Nitroso hydroxy Cetrizine EP Impurity-A (4-Fluoro-2-methoxy-5-nitro- phenyl)-[4- (1-methyl-1H- indol-3- yl)-pyrimidin-2-yl]- amine 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole tert-butyl 4-(6-((7-cyclo pentyl -6-(dimethyl carbamoyl) -7H-pyrrolo [2,3-d]pyrimidin-2-yl) amino)pyridin-3-yl) piperazine-1-carboxylate 2-Fluoro-4-nitrotoluene 1-(2-amino-5-hydroxy phenyl)propan-1-one (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3- amine 3-(Dimethylamino)benzoic acid 2-Amino-5-chloropyridine 4-(Methylamino)-3-nitrobenzoic Acid 5-Chloro-2-Nitroaniline 3,5-dibenzyloxy Acetophenone 2,4-Diamino-6-hydroxypyrimidine 2-Chloro Benzylcyanide 3-chlorobenzyl cyanide 3,4 Diethoxy BenzylcyanideRelated products of tetrahydrofuran
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