2-Chloropyrazine
- CAS NO.：14508-49-7
- Empirical Formula: C4H3ClN2
- Molecular Weight: 114.53
- MDL number: MFCD00006124
- EINECS: 238-517-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-17 20:01:48
What is 2-Chloropyrazine?
Chemical properties
clear colorless to yellowish liquid
The Uses of 2-Chloropyrazine
2-Chloropyrazine is used in cardiotonic, in biological, drug, flavoring and perfumery industry.
What are the applications of Application
2-Chloropyrazine is used as a reagent in the synthesis of hetaryloxy benzoxaborole compounds which have antimalarial activity. 2-Chloropyrazine is also used to prepare 4,5-disubstituted 6-aryloxy-1,3-dihydrobenzo[c][1,2]oxaboroles which are broad-spectrum serine β-lactamase inhibitors.
Definition
ChEBI: 2-chloropyrazine is a member of pyrazines.
Purification Methods
Fractionally distil it through a short column packed with glass helices. It has apenetrating, mildly pungent odour with a high vapour pressure at room temperature. [Erickson & Spoerri J Am Chem Soc 68 400 1946, Hetman & O.Donnell J Org Chem 28 1682 1963, Beilstein 23/5 V 366.]
Properties of 2-Chloropyrazine
| Melting point: | 153～154℃ |
| Boiling point: | 153-154 °C (lit.) |
| Density | 1.283 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 136 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in Methanol |
| form | Liquid |
| pka | -1.10±0.10(Predicted) |
| Specific Gravity | 1.283 |
| color | Clear colorless to yellow |
| Water Solubility | INSOLUBLE |
| BRN | 107019 |
| CAS DataBase Reference | 14508-49-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Chloropyrazine(14508-49-7) |
| EPA Substance Registry System | Pyrazine, chloro- (14508-49-7) |
Safety information for 2-Chloropyrazine
| Signal word | Warning |
| Pictogram(s) |
 Flame Flammables GHS02 |
| GHS Hazard Statements |
H226:Flammable liquids |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P370+P378:In case of fire: Use … for extinction. |
Computed Descriptors for 2-Chloropyrazine
2-Chloropyrazine manufacturer
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