2-chloroethanesulfonyl chloride
Synonym(s):2-Chloro-1-ethanesulfonyl chloride
- CAS NO.：1622-32-8
- Empirical Formula: C2H4Cl2O2S
- Molecular Weight: 163.02
- MDL number: MFCD00007461
- EINECS: 216-594-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-09-25 17:15:13
What is 2-chloroethanesulfonyl chloride?
Chemical properties
CLEAR SLIGHTLY YELLOW TO BROWN LIQUID
The Uses of 2-chloroethanesulfonyl chloride
2-Chloroethanesulfonyl chloride was used in one-pot sulfonylation/intramolecular thia-Michael protocol for the synthesis of 1,5,2-dithiazepine 1,1-dioxides. It was also used in synthesis of vinyl sulfonamides with a furan, carbocyclic, semi cyclic or acyclic 1,3-diene moiety.
General Description
A liquid. Density 1.56 g / cm3. Flash point exceeds 230°F.
Air & Water Reactions
Reacts with water to produce corrosive and toxic gaseous hydrogen chloride.
Reactivity Profile
2-CHLOROETHANESULFONYL CHLORIDE is incompatible with strong oxidizing agents, alcohols, amines, alkali. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Properties of 2-chloroethanesulfonyl chloride
| Melting point: | 3 °C |
| Boiling point: | 84-86 °C15 mm Hg(lit.) |
| Density | 1.56 g/mL at 25 °C(lit.) |
| vapor pressure | 15 mm Hg ( 84 °C) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Refrigerator |
| form | Liquid |
| color | Clear slightly yellow to brown |
| Water Solubility | Reacts with water. |
| Sensitive | Moisture Sensitive |
| BRN | 1751202 |
| CAS DataBase Reference | 1622-32-8(CAS DataBase Reference) |
| EPA Substance Registry System | 2-Chloro-ethanesulfonyl chloride (1622-32-8) |
Safety information for 2-chloroethanesulfonyl chloride
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H314:Skin corrosion/irritation H330:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-chloroethanesulfonyl chloride
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