2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
- CAS NO.：65836-72-8
- Empirical Formula: C11H14ClNO3
- Molecular Weight: 243.69
- MDL number: MFCD01733639
- EINECS: 604-604-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-27 17:00:41
What is 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE?
Biological Activity
DKM 2-93 is a relatively selective UBA5 inhibitor with IC50 value of 430 μM.
in vitro
Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC 50 s of 90 and 30 μM, respectively.
in vivo
DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity.
Properties of 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
| Melting point: | 116-118 °C(Solv: carbon tetrachloride (56-23-5)) |
| Boiling point: | 425.7±45.0 °C(Predicted) |
| Density | 1.194±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 150 mg/mL (615.54 mM) |
| form | Solid |
| pka | 13.42±0.46(Predicted) |
| color | White to light yellow |
Safety information for 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H311:Acute toxicity,dermal H331:Acute toxicity,inhalation H341:Germ cell mutagenicity |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P330:Rinse mouth. P361:Remove/Take off immediately all contaminated clothing. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..… |
Computed Descriptors for 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
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