2-Chloro-4-methoxypyridine
- CAS NO.：17228-69-2
- Empirical Formula: C6H6ClNO
- Molecular Weight: 143.57
- MDL number: MFCD02093951
- EINECS: 625-435-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 01:13:37
What is 2-Chloro-4-methoxypyridine?
Chemical properties
Colorless liquid
The Uses of 2-Chloro-4-methoxypyridine
2-Chloro-4-methoxypyridine may be used to synthesize:
- 2-(2′,4′-difluorophenyl)-4-methoxypyridine
- (2-chloro-4-methoxypyridin-3-yl)bis-[2-(methylsulfanyl)pyrimidin-4-yl]methanol
- (2-chloro-4-methoxypyridin-3-yl)bis-[2-(methylsulfanyl) pyrimidin-4-yl]methyl acetate
The Uses of 2-Chloro-4-methoxypyridine
It is an active pharmaceutical ingredient.
General Description
2-Chloro-4-methoxypyridine can be obtained from the reaction between 2-chloro-4-nitropyridine and sodium methoxide in the presence of dioxane. It can also be prepared starting from 4-methoxy-2(1H)-pyridone and 4-nitropyridine N-oxide.
Properties of 2-Chloro-4-methoxypyridine
| Boiling point: | 224-225 °C (lit.) |
| Density | 1.258 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in alcohol. |
| form | Liquid |
| pka | 2.25±0.10(Predicted) |
| Specific Gravity | 1.258 |
| color | Colorless to pale yellow |
| BRN | 1423379 |
| CAS DataBase Reference | 17228-69-2(CAS DataBase Reference) |
Safety information for 2-Chloro-4-methoxypyridine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Chloro-4-methoxypyridine
| InChIKey | PMTPFBWHUOWTNN-UHFFFAOYSA-N |
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