2-Chloro-4-methoxypyridine

CAS NO.：17228-69-2
Empirical Formula: C6H6ClNO
Molecular Weight: 143.57
MDL number: MFCD02093951
EINECS: 625-435-9
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 01:13:37

What is 2-Chloro-4-methoxypyridine?

Chemical properties

Colorless liquid

The Uses of 2-Chloro-4-methoxypyridine

It is an active pharmaceutical ingredient.

The Uses of 2-Chloro-4-methoxypyridine

2-Chloro-4-methoxypyridine may be used to synthesize:

2-(2′,4′-difluorophenyl)-4-methoxypyridine
(2-chloro-4-methoxypyridin-3-yl)bis-[2-(methylsulfanyl)pyrimidin-4-yl]methanol
(2-chloro-4-methoxypyridin-3-yl)bis-[2-(methylsulfanyl) pyrimidin-4-yl]methyl acetate

General Description

2-Chloro-4-methoxypyridine can be obtained from the reaction between 2-chloro-4-nitropyridine and sodium methoxide in the presence of dioxane. It can also be prepared starting from 4-methoxy-2(1H)-pyridone and 4-nitropyridine N-oxide.

Properties of 2-Chloro-4-methoxypyridine

Boiling point:	224-225 °C (lit.)
Density	1.258 g/mL at 25 °C (lit.)
refractive index	n20/D 1.5400(lit.)
Flash point:	>230 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Soluble in alcohol.
form	Liquid
pka	2.25±0.10(Predicted)
Specific Gravity	1.258
color	Colorless to pale yellow
BRN	1423379
CAS DataBase Reference	17228-69-2(CAS DataBase Reference)

Safety information for 2-Chloro-4-methoxypyridine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.