2-Bromo-4'-nitroacetophenone
Synonym(s):ω-Bromo-4-nitroacetophenone;4-Nitrophenacyl bromide
- CAS NO.：99-81-0
- Empirical Formula: C8H6BrNO3
- Molecular Weight: 244.04
- MDL number: MFCD00007356
- EINECS: 202-789-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:20:08
What is 2-Bromo-4'-nitroacetophenone?
Chemical properties
yellow to orange crystalline powder
The Uses of 2-Bromo-4'-nitroacetophenone
2-Bromo-4′-nitroacetophenone was used to study the pKa of the histidine-34 imidazole.
Synthesis Reference(s)
Synthesis, p. 487, 1980 DOI: 10.1055/s-1980-29067
Purification Methods
Crystallise it from *C6H6/pet ether. [Beilstein 7 IV 661.]
Properties of 2-Bromo-4'-nitroacetophenone
| Melting point: | 94-99 °C(lit.) |
| Boiling point: | 325.2±17.0 °C(Predicted) |
| Density | 1.8033 (rough estimate) |
| refractive index | 1.6090 (estimate) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | Crystalline Powder |
| color | Yellow to orange |
| BRN | 393567 |
| CAS DataBase Reference | 99-81-0(CAS DataBase Reference) |
| NIST Chemistry Reference | p-Nitrophenacyl bromide(99-81-0) |
| EPA Substance Registry System | 2-Bromo-4'-nitroacetophenone (99-81-0) |
Safety information for 2-Bromo-4'-nitroacetophenone
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Bromo-4'-nitroacetophenone
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