2-(Aminomethyl)-18-crown-6
Synonym(s):1,4,7,10,13,16-Hexaoxacyclooctadecane-2-methanamine
- CAS NO.：83585-61-9
- Empirical Formula: C13H27NO6
- Molecular Weight: 293.36
- MDL number: MFCD00191741
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:49:08
What is 2-(Aminomethyl)-18-crown-6?
The Uses of 2-(Aminomethyl)-18-crown-6
2-Aminomethyl-18-crown-6 (AM-18-C-6) can be used to prepare:
- AM-18-C-6 bonded Merrifield peptide resin, which is used to study the absorption and the isotopic effect of magnesium.
- Schiff base of gossypol with aminomethyl crown ether for complexation of monovalent cations.
- Crown tagged triarylphosphine by reacting with triphenylphosphine carboxylic acid. These tagged triarylphosphine reagents are used in Mitsunobu and Heck reactions for the removal of phosphine derived by-products.
- 1,16-hexadecanoyl-bis-(2-aminomethyl)-18-crown-6 (bola A-16), which is utilized as a vesicular carrier in a drug delivery system.
Properties of 2-(Aminomethyl)-18-crown-6
| Boiling point: | 135 °C/0.08 mmHg (lit.) |
| Density | 1.126 g/mL at 25 °C (lit.) |
| refractive index | n20/D 1.479(lit.) |
| Flash point: | 113 °C |
| pka | 9.11±0.29(Predicted) |
| BRN | 4184588 |
Safety information for 2-(Aminomethyl)-18-crown-6
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-(Aminomethyl)-18-crown-6
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