N1-(4-Chlorophenyl)benzene-1,2-diamine
Synonym(s):2-Amino-4′-chlorodiphenylamine
- CAS NO.：68817-71-0
- Empirical Formula: C12H11ClN2
- Molecular Weight: 218.68
- MDL number: MFCD00007686
- EINECS: 272-391-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:18:34
What is N1-(4-Chlorophenyl)benzene-1,2-diamine?
The Uses of N1-(4-Chlorophenyl)benzene-1,2-diamine
N-(4-Chlorophenyl)-1,2-phenylenediamine is a reagent in the synthesis of clofazimine analogs as antileishmanials and antiplasmodials.
The Uses of N1-(4-Chlorophenyl)benzene-1,2-diamine
N-(4-Chlorophenyl)-1,2-phenylenediamine (2-Amino-4′-chlorodiphenylamine) was used in preparation of N-(p-chloro)phenylbenzimidazolin-2-one and monoaminophenazine dyes.
Synthesis
To a mixture of EtOH (100 ml) and NH4C1 saturated solution (15 ml), N-(4-chlorophenyl)-2-nitrobenzenamine (5.0 g, 20.1 mmol) was added, followed by iron powder (4.0 g). The reaction mixture was heated at 70 °C for 2h. The solid was filtered, and the filtrate was extracted by EA (100 mL x 3) and dried over Na2S04. After the solvent was removed, the mixture was purified by Combi-flash (PE: EA = 5 : 1) to give N1-(4-Chlorophenyl)benzene-1,2-diamine (4.1 g, 93.2 percent) as a light yellow solid.
Properties of N1-(4-Chlorophenyl)benzene-1,2-diamine
| Melting point: | 117-119 °C(lit.) |
| Boiling point: | 357.0±27.0 °C(Predicted) |
| Density | 1.288±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 4.90±0.10(Predicted) |
| InChI | InChI=1S/C12H11ClN2/c13-9-5-7-10(8-6-9)15-12-4-2-1-3-11(12)14/h1-8,15H,14H2 |
Safety information for N1-(4-Chlorophenyl)benzene-1,2-diamine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N1-(4-Chlorophenyl)benzene-1,2-diamine
| InChIKey | WEUBIWJPIRTWDF-UHFFFAOYSA-N |
| SMILES | C1(NC2=CC=C(Cl)C=C2)=CC=CC=C1N |
N1-(4-Chlorophenyl)benzene-1,2-diamine manufacturer
New Products
Cyclopropane-1,1-dicarboxylic acid Cefuroxime EP Impurity-A N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity tert-Butyl (2S)-[1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl]carbamate 4-amino-2-fluoro-N- methylbenzamide 5-Chloro-3- Methyl -1,3-2-benzoxazol-2(3H)-one N-(2-chloropyrimidin-4-yl)-N,2,3- trimethyl-2H- indazol 6-amine N-Boc-1,4-butanediamine 4-Bromo-2-fluoro-N-methylbenzamide valeronitrile 3-chlorobenzyl cyanide 3,4 Dimethoxy Benzylcyanide 3,4 Diethoxy Benzylcyanide 2-Chloro Benzylcyanide 3-Hydroxypropionitrile 5-azidovalericacid 6,6'-bis(difluoromethoxy)-2,2'-bis((3,4-dimethoxypyridin-2-yl)methylsulfinyl)-1H,1'H-5,5'-bibenzo[d]imidazole (1-((2'-(2-((1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methyl)-2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol (1-((2'-(1-((1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methyl)-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol (4-Methoxyphenyl) hydrazine HydrochlorideRelated products of tetrahydrofuran
![CLOFAZIMINE, [METHYL-3H]](https://img.chemicalbook.in/StructureFile/ChemBookStructure4/GIF/CB4315311.gif)
You may like
-
68817-71-0 N-(4-chlorophenyl)-1,2-phenylenediamine 98%View Details
68817-71-0 -
68817-71-0 98%View Details
68817-71-0 -
N-(4-Chlorophenyl)-1,2-phenylenediamine 98%View Details
68817-71-0 -
N-(4-Chorophenyl)-1,2-benzenediamine 68817-71-0 98%View Details
68817-71-0 -
N-(4-Chorophenyl)-1,2-benzenediamine 68817-71-0 99%View Details
68817-71-0 -
N-(4-Chlorophenyl)-1,2-phenylenediamine 95% CAS 68817-71-0View Details
68817-71-0 -
N-(4-Chlorophenyl)-1,2-phenylenediamine CAS 68817-71-0View Details
68817-71-0 -
68817-71-0 98%View Details
68817-71-0
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.