2-AMINO-2-NORBORNANECARBOXYLIC ACID
Synonym(s):2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid;BCH
- CAS NO.：20448-79-7
- Empirical Formula: C8H13NO2
- Molecular Weight: 155.19
- MDL number: MFCD00167580
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-16 07:06:08
What is 2-AMINO-2-NORBORNANECARBOXYLIC ACID?
The Uses of 2-AMINO-2-NORBORNANECARBOXYLIC ACID
2-Amino-2-norbornanecarboxylic Acid functions in the suppressive effect of I-type amino acid transporter 1 inhibition as therapeutic target on human esophageal squamous cell carcinoma. Also use in the design and preparation of KMH-233, selective and slowly reversible inhibitor of L-type amino acid transporter 1 (LAT1) which potentiates antiproliferative drug efficacy in cancer cells
What are the applications of Application
2-Amino-2-norbornanecarboxylic acid is An inhibitor of amino acid transport across cell membranes
Definition
ChEBI: 2-Amino-2-norbornanecarboxylic acid is a monoterpenoid.
General Description
2-Amino-2-norbornanecarboxylic acid is a potential large amino acid transporters inhibitor. It may suppress tumor progression and apoptosis.
Biochem/physiol Actions
2-Amino-2-norbornanecarboxylic acid (BCH) is a Na(+)-independent system L specific substrate used with other system specific substrates such as the system A specific substrate α-(methylamino) isobutyric acid and system N specific substrate L-glutamic acid gamma-monohydroxamate to help identify, differentiate and characterize amino acid transport systems in cells.
Storage
Store at RT
Properties of 2-AMINO-2-NORBORNANECARBOXYLIC ACID
| Melting point: | >300 °C(lit.) |
| Boiling point: | 295.5±23.0 °C(Predicted) |
| Density | 1.256±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Aqueous Acid (Slightly) |
| form | Solid |
| pka | 2.58±0.20(Predicted) |
| color | White |
| Water Solubility | Soluble to 100 mM in water |
| CAS DataBase Reference | 20448-79-7(CAS DataBase Reference) |
Safety information for 2-AMINO-2-NORBORNANECARBOXYLIC ACID
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-AMINO-2-NORBORNANECARBOXYLIC ACID
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![BICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID](https://img.chemicalbook.in/CAS/GIF/824-62-4.gif)
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