2-AMINO-2-NORBORNANECARBOXYLIC ACID

Synonym(s):2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid;BCH

CAS NO.：20448-79-7
Empirical Formula: C8H13NO2
Molecular Weight: 155.19
MDL number: MFCD00167580
SAFETY DATA SHEET (SDS)
Update Date: 2025-11-02 10:48:33

2-AMINO-2-NORBORNANECARBOXYLIC ACID Structural

What is 2-AMINO-2-NORBORNANECARBOXYLIC ACID?

The Uses of 2-AMINO-2-NORBORNANECARBOXYLIC ACID

2-Amino-2-norbornanecarboxylic Acid functions in the suppressive effect of I-type amino acid transporter 1 inhibition as therapeutic target on human esophageal squamous cell carcinoma. Also use in the design and preparation of KMH-233, selective and slowly reversible inhibitor of L-type amino acid transporter 1 (LAT1) which potentiates antiproliferative drug efficacy in cancer cells

What are the applications of Application

2-Amino-2-norbornanecarboxylic acid is An inhibitor of amino acid transport across cell membranes

Definition

ChEBI: 2-Amino-2-norbornanecarboxylic acid is a monoterpenoid.

General Description

2-Amino-2-norbornanecarboxylic acid is a potential large amino acid transporters inhibitor. It may suppress tumor progression and apoptosis.

Biochem/physiol Actions

2-Amino-2-norbornanecarboxylic acid (BCH) is a Na(+)-independent system L specific substrate used with other system specific substrates such as the system A specific substrate α-(methylamino) isobutyric acid and system N specific substrate L-glutamic acid gamma-monohydroxamate to help identify, differentiate and characterize amino acid transport systems in cells.

Storage

Store at RT

Properties of 2-AMINO-2-NORBORNANECARBOXYLIC ACID

Melting point:	>300 °C(lit.)
Boiling point:	295.5±23.0 °C(Predicted)
Density	1.256±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Aqueous Acid (Slightly)
form	Solid
pka	2.58±0.20(Predicted)
color	White
Water Solubility	Soluble to 100 mM in water
CAS DataBase Reference	20448-79-7(CAS DataBase Reference)

Safety information for 2-AMINO-2-NORBORNANECARBOXYLIC ACID

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.