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HomeProduct name list2-(4-Aminophenyl)ethylamine

2-(4-Aminophenyl)ethylamine

Synonym(s):4-Aminophenethylamine

  • CAS NO.:13472-00-9
  • Empirical Formula: C8H12N2
  • Molecular Weight: 136.19
  • MDL number: MFCD00008194
  • EINECS: 236-739-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2026-05-28 02:01:51
2-(4-Aminophenyl)ethylamine Structural

What is 2-(4-Aminophenyl)ethylamine?

Chemical properties

clear light yellow to brown-yellow viscous liquid

The Uses of 2-(4-Aminophenyl)ethylamine

4-(2-Aminoethyl)aniline has been used in chemical modification of silk fibroin to tailor the overall hydrophilicity and structure of silk. It has been used as reagent in polycondensation reactions.

What are the applications of Application

4-(2-Aminoethyl)aniline is used in polycondensation reactions.

What are the applications of Application

2-(4-Aminophenyl)ethylamine (APEA) is an important amine compound for the study of reductive amination with 3-deoxy-d-mannuronic acid (Kdo) and for the synthesis of new heat-resistant biopolyureas by fermentation techniques[1-2].

Synthesis Reference(s)

Tetrahedron Letters, 25, p. 5219, 1984 DOI: 10.1016/S0040-4039(01)81568-9

General Description

4-(2-Aminoethyl)aniline undergoes coupling with carbohydrates by reductive amination to yield modified carbohydrates.

References

[1] H D GRIMMECKE; H B. Studies on the reductive amination of 3-deoxy-D-manno-octulosonic acid (Kdo).[J]. Glycoconjugate Journal, 1998. DOI:10.1023/a:1006955508077.
[2] HAJIME MINAKAWA. Fermentative production of 2-(4-aminophenyl)ethylamine to synthesize a novel heat-resistant biopolyurea.[J]. Bioscience, Biotechnology, and Biochemistry, 2022. DOI:10.1093/bbb/zbac077.

Properties of 2-(4-Aminophenyl)ethylamine

Melting point: 28-31 °C(lit.)
Boiling point: 103 °C0.3 mm Hg(lit.)
Density  1.034 g/mL at 25 °C(lit.)
refractive index  n20/D 1.591(lit.)
Flash point: >230 °F
storage temp.  under inert gas (nitrogen or Argon) at 2–8 °C
solubility  Chloroform (Slightly), Methanol (Slightly)
form  Viscous Liquid
pka 10.32±0.10(Predicted)
color  Clear light yellow to brown-yellow
Water Solubility  Insoluble in water.
Sensitive  Air Sensitive
BRN  1099913
Stability: Air Sensitive
CAS DataBase Reference 13472-00-9(CAS DataBase Reference)
NIST Chemistry Reference 2-(4-Aminophenyl)ethylamine(13472-00-9)

Safety information for 2-(4-Aminophenyl)ethylamine

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
GHS Hazard Statements H314:Skin corrosion/irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P363:Wash contaminated clothing before reuse.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for 2-(4-Aminophenyl)ethylamine

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