2-(4-Aminophenyl)ethylamine
Synonym(s):4-Aminophenethylamine
- CAS NO.:13472-00-9
- Empirical Formula: C8H12N2
- Molecular Weight: 136.19
- MDL number: MFCD00008194
- EINECS: 236-739-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 02:01:51
What is 2-(4-Aminophenyl)ethylamine?
Chemical properties
clear light yellow to brown-yellow viscous liquid
The Uses of 2-(4-Aminophenyl)ethylamine
4-(2-Aminoethyl)aniline has been used in chemical modification of silk fibroin to tailor the overall hydrophilicity and structure of silk. It has been used as reagent in polycondensation reactions.
What are the applications of Application
4-(2-Aminoethyl)aniline is used in polycondensation reactions.
What are the applications of Application
2-(4-Aminophenyl)ethylamine (APEA) is an important amine compound for the study of reductive amination with 3-deoxy-d-mannuronic acid (Kdo) and for the synthesis of new heat-resistant biopolyureas by fermentation techniques[1-2].
Synthesis Reference(s)
Tetrahedron Letters, 25, p. 5219, 1984 DOI: 10.1016/S0040-4039(01)81568-9
General Description
4-(2-Aminoethyl)aniline undergoes coupling with carbohydrates by reductive amination to yield modified carbohydrates.
References
[1] H D GRIMMECKE; H B. Studies on the reductive amination of 3-deoxy-D-manno-octulosonic acid (Kdo).[J]. Glycoconjugate Journal, 1998. DOI:10.1023/a:1006955508077.
[2] HAJIME MINAKAWA. Fermentative production of 2-(4-aminophenyl)ethylamine to synthesize a novel heat-resistant biopolyurea.[J]. Bioscience, Biotechnology, and Biochemistry, 2022. DOI:10.1093/bbb/zbac077.
Properties of 2-(4-Aminophenyl)ethylamine
| Melting point: | 28-31 °C(lit.) |
| Boiling point: | 103 °C0.3 mm Hg(lit.) |
| Density | 1.034 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Viscous Liquid |
| pka | 10.32±0.10(Predicted) |
| color | Clear light yellow to brown-yellow |
| Water Solubility | Insoluble in water. |
| Sensitive | Air Sensitive |
| BRN | 1099913 |
| Stability: | Air Sensitive |
| CAS DataBase Reference | 13472-00-9(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-(4-Aminophenyl)ethylamine(13472-00-9) |
Safety information for 2-(4-Aminophenyl)ethylamine
| Signal word | Danger |
| Pictogram(s) |
![]() Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 2-(4-Aminophenyl)ethylamine
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