Phenetidine

Synonym(s):p-Phenetidine;4-Ethoxyaniline

CAS NO.：156-43-4
Empirical Formula: C8H11NO
Molecular Weight: 137.18
MDL number: MFCD00007865
EINECS: 205-855-5
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-25 17:15:13

What is Phenetidine?

Chemical properties

colourless liquid

The Uses of Phenetidine

A toxic metabolite of Phenacetin (P294580) which exhibits high renal toxicity. p-Phenetidine also reduced COX-1 and COX-2 expression in neutrophils.

Definition

ChEBI: An aromatic ether that is aniline in which the hydrogen at position 4 is replaced by an ethoxy group. It is a hydrolysis metabolite of phenacetin.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 27, p. 347, 1984 DOI: 10.1021/jm00369a019

General Description

Colorless to dark red liquid.

Air & Water Reactions

Very sensitive to exposure to air and light. Turns red to brown on exposure to light and air. . Slightly soluble in water.

Reactivity Profile

Phenetidine reacts vigorously with powerful oxidizers.

Fire Hazard

Phenetidine is combustible.

Safety Profile

Poison by inhalation. Moderately toxic by ingestion and intraperitoneal routes. Caution: It can be absorbed through the skin. A skin and eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Properties of Phenetidine

Melting point:	2-5 °C(lit.)
Boiling point:	250 °C(lit.)
Density	1.065 g/mL at 25 °C(lit.)
vapor pressure	2.93Pa at 25℃
refractive index	n20/D 1.559(lit.)
Flash point:	240 °F
storage temp.	2-8°C
solubility	20g/l
form	A liquid
pka	5.2(at 28℃)
color	Clear Yellow
PH	8 (1g/l, H2O, 20℃)
Water Solubility	practically insoluble
Sensitive	Air Sensitive
Merck	14,7228
BRN	606666
Dielectric constant	7.3（21℃）
Stability:	Stable, but light and air sensitive. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference	156-43-4(CAS DataBase Reference)
NIST Chemistry Reference	4-Ethoxyaniline(156-43-4)
EPA Substance Registry System	p-Phenetidine (156-43-4)

Safety information for Phenetidine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H341:Germ cell mutagenicity
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention.