Phenetidine
Synonym(s):p-Phenetidine;4-Ethoxyaniline
- CAS NO.：156-43-4
- Empirical Formula: C8H11NO
- Molecular Weight: 137.18
- MDL number: MFCD00007865
- EINECS: 205-855-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:13:00
What is Phenetidine?
Chemical properties
colourless liquid
The Uses of Phenetidine
A toxic metabolite of Phenacetin (P294580) which exhibits high renal toxicity. p-Phenetidine also reduced COX-1 and COX-2 expression in neutrophils.
Definition
ChEBI: An aromatic ether that is aniline in which the hydrogen at position 4 is replaced by an ethoxy group. It is a hydrolysis metabolite of phenacetin.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 27, p. 347, 1984 DOI: 10.1021/jm00369a019
General Description
Colorless to dark red liquid.
Air & Water Reactions
Very sensitive to exposure to air and light. Turns red to brown on exposure to light and air. . Slightly soluble in water.
Reactivity Profile
Phenetidine reacts vigorously with powerful oxidizers.
Fire Hazard
Phenetidine is combustible.
Safety Profile
Poison by inhalation. Moderately toxic by ingestion and intraperitoneal routes. Caution: It can be absorbed through the skin. A skin and eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Properties of Phenetidine
| Melting point: | 2-5 °C(lit.) |
| Boiling point: | 250 °C(lit.) |
| Density | 1.065 g/mL at 25 °C(lit.) |
| vapor pressure | 2.93Pa at 25℃ |
| refractive index | n |
| Flash point: | 240 °F |
| storage temp. | 2-8°C |
| solubility | 20g/l |
| form | A liquid |
| pka | 5.2(at 28℃) |
| color | Clear Yellow |
| PH | 8 (1g/l, H2O, 20℃) |
| Water Solubility | practically insoluble |
| Sensitive | Air Sensitive |
| Merck | 14,7228 |
| BRN | 606666 |
| Dielectric constant | 7.3（21℃） |
| Stability: | Stable, but light and air sensitive. Combustible. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 156-43-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Ethoxyaniline(156-43-4) |
| EPA Substance Registry System | p-Phenetidine (156-43-4) |
Safety information for Phenetidine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H341:Germ cell mutagenicity |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for Phenetidine
| InChIKey | IMPPGHMHELILKG-UHFFFAOYSA-N |
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