18-HYDROXY-11-DEOXYCORTICOSTERONE
- CAS NO.：379-68-0
- Empirical Formula: C21H30O4
- Molecular Weight: 346.46
- MDL number: MFCD00010486
- EINECS: 2068343
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:11:09
What is 18-HYDROXY-11-DEOXYCORTICOSTERONE?
Description
18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland. Its biosynthesis is regulated by adrenocorticotropic hormone (ACTH; ) as well as angiotensin II , which increases 18-OH-DOC production in isolated human adrenal glomerulosa cells. 18-OH-DOC can be formed via conversion of 11-deoxy corticosterone (DOC; ) in human SK-MEL188 melanoma cells. 18-OH-DOC is an intermediate in the metabolism of progesterone and can be converted to aldosterone by the capsular portion of rat adrenal glands. Continuous infusion of 18-OH-DOC (200 μg/rat per day) increases systolic blood pressure in uninephrectomized saline-drinking rats. Plasma levels of 18-OH-DOC are elevated in a db/db mouse model of type 2 diabetes.
The Uses of 18-HYDROXY-11-DEOXYCORTICOSTERONE
11-Deoxy-18-hydroxycorticosterone is an analog of Corticosterone (C695700); a glucocorticoid and intermediate in the biosynthesis of Aldosterone (A514700) which is an adrenocortical steroid isolated from the adrenal cortex.
Definition
ChEBI: 18-hydroxydeoxycorticosterone is a 21-hydroxy steroid, a 3-oxo-Delta(4) steroid, a 20-oxo steroid and a 18-hydroxy steroid.
Purification Methods
Recrystallise 18-hydroxy-11-deoxycorticosterone from Et2O/Me2CO to give crystals m 200-205o. When it is recrystallised from M2CO, it has m 191-195o. It has UV with max at 240nm. The 21-O-acetoxy-18-hydroxy derivative has m 158-159o (from Et2O/*C6H6), and the 21-O-acetoxy-18,20-epoxy derivative has m 149-154o (from Et2O). [Kahnt et al. Helv Chim Acta 38 1237 1955; Pappo J Am Chem Soc 81 1010 1959.]
Properties of 18-HYDROXY-11-DEOXYCORTICOSTERONE
| Melting point: | 171-173 °C |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly, Sonicated), Methanol (Slightly, Heated) |
| form | Solid |
| color | White to Off-White |
Safety information for 18-HYDROXY-11-DEOXYCORTICOSTERONE
Computed Descriptors for 18-HYDROXY-11-DEOXYCORTICOSTERONE
New Products
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