1,3-Dioxan-2-one

CAS NO.：2453-03-4
Empirical Formula: C4H6O3
Molecular Weight: 102.09
MDL number: MFCD00010440
EINECS: 607-395-4
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:15:29

What is 1,3-Dioxan-2-one?

Description

1,3-Dioxan-2-one is a cyclic carbonate ester with the chemical formula C4H6O3. 1,3-Dioxan-2-one, also known as Trimethylene Carbonate, is a colorless solid and 6-membered cyclic carbonate ester used to manufacture medical device biodegradable polymers. This potential monomer continues to play an overwhelming role in synthesizing aliphatic polycarbonates and polyurethanes, which are of interest for biomedical applications because of their low toxicity and biodegradability. The most common preparation of 1,3-dioxan-2-one (six-membered cyclic carbonate) monomers involves the reaction of 1,3-diols with phosgene derivatives or carbon monoxide[1].

References

[1] Hosseinian, Akram et al. “Advancements in six-membered cyclic carbonate (1,3-dioxan-2-one) synthesis utilizing carbon dioxide as a C1 source.” RSC Advances 32 (2018): 17976–17988.

Properties of 1,3-Dioxan-2-one

Melting point:	45.0 to 49.0 °C
Boiling point:	135°C/4mmHg(lit.)
Density	1.200±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	soluble in Methanol
form	powder to crystal
color	White to Almost white

Safety information for 1,3-Dioxan-2-one

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection.