1,3-Dioxan-2-one
- CAS NO.：2453-03-4
- Empirical Formula: C4H6O3
- Molecular Weight: 102.09
- MDL number: MFCD00010440
- EINECS: 607-395-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:15:29
What is 1,3-Dioxan-2-one?
Description
1,3-Dioxan-2-one is a cyclic carbonate ester with the chemical formula C4H6O3. 1,3-Dioxan-2-one, also known as Trimethylene Carbonate, is a colorless solid and 6-membered cyclic carbonate ester used to manufacture medical device biodegradable polymers. This potential monomer continues to play an overwhelming role in synthesizing aliphatic polycarbonates and polyurethanes, which are of interest for biomedical applications because of their low toxicity and biodegradability. The most common preparation of 1,3-dioxan-2-one (six-membered cyclic carbonate) monomers involves the reaction of 1,3-diols with phosgene derivatives or carbon monoxide[1].
References
[1] Hosseinian, Akram et al. “Advancements in six-membered cyclic carbonate (1,3-dioxan-2-one) synthesis utilizing carbon dioxide as a C1 source.” RSC Advances 32 (2018): 17976–17988.
Properties of 1,3-Dioxan-2-one
| Melting point: | 45.0 to 49.0 °C |
| Boiling point: | 135°C/4mmHg(lit.) |
| Density | 1.200±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Methanol |
| form | powder to crystal |
| color | White to Almost white |
Safety information for 1,3-Dioxan-2-one
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 1,3-Dioxan-2-one
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