1,2,3,6-Tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine oxalate

CAS NO.：154130-99-1
Empirical Formula: C18H22N2O
Molecular Weight: 282.38
MDL number: MFCD00924135
SAFETY DATA SHEET (SDS)
Update Date: 2026-09-12 18:48:00

What is 1,2,3,6-Tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine oxalate?

The Uses of 1,2,3,6-Tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine oxalate

PD 144418 is high affinity, selective σ1 ligand (Ki values are 0.08 and 1377 nM for σ1 and σ2 respectively). PD 144418 displays no significant activity at a wide range of other receptors, ion channels and enzymes. PD 144418 antagonizes mescaline-induced scratching in mice following i.p. administration.

What are the applications of Application

PD 144418 oxalate is a selective σ1 ligand displaying high selectivity.

Biological Activity

High affinity, selective σ 1 ligand (K i values are 0.08 and 1377 nM for σ 1 and σ 2 respectively). Displays no significant activity at a wide range of other receptors, ion channels and enzymes. Antagonizes mescaline-induced scratching in mice following i.p. administration.

Properties of 1,2,3,6-Tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine oxalate

Boiling point:	453.2±45.0 °C(Predicted)
Density	1.067±0.06 g/cm3(Predicted)
storage temp.	Desiccate at RT
solubility	<18.62mg/ml in DMSO
form	solid
pka	8.10±0.40(Predicted)
color	Off-white

Safety information for 1,2,3,6-Tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine oxalate

Computed Descriptors for 1,2,3,6-Tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine oxalate

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1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE