1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene

CAS NO.：6683-46-1
Empirical Formula: C14H20
Molecular Weight: 188.31
MDL number: MFCD00052728
EINECS: 229-723-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 02:20:50

What is 1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene?

The Uses of 1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene

1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene can be used as an intermediate to participate in a variety of chemical reactions and is used in the synthesis of a variety of compounds and drugs. For example, 6-lodo-1,1,4,4-tetramethyl-l,2,3,4-tetrahydronaphthalene, 6-bromo-1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthalene and 1,1,4,4-tetramethyl-6-nitro-1,2,3,4- tetrahydronaphthalene and others.

Preparation

2,5-dichloro-2,5- dimethylhexane (300 mg, 1.64 mmol, 1 eq) was dissolved in dry benzene (25 mL). Then added AlCl₃(22.0 mg, 0.164 mmol, 0.1 eq) to the solution, which was stirred at reflux for 16 hours. The reaction was stopped with 3M HCl (5 mL) and extracted with hexanes (10 mL x 3). The combined organic layer was washed with brine, dried with Na2S04, filtered, and concentrated in vacuo. Finally, the crude was purified by flash chromatography (100% hexanes) to obtained the colourless oil (1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene).Yield=91%
1,2,3,4-TETRAHYDRO-1,1,4,4-TETRAMETHYLNAPHTHALENE

Properties of 1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene

Melting point:	115-120℃
Boiling point:	63 °C
Density	0.9482 g/cm3(Temp: 27 °C)
refractive index	1.5278 (589.3 nm 27℃)
storage temp.	2-8°C
color	Clear, pale yellow
InChI	InChI=1S/C14H20/c1-13(2)9-10-14(3,4)12-8-6-5-7-11(12)13/h5-8H,9-10H2,1-4H3
EPA Substance Registry System	Naphthalene, 1,2,3,4-tetrahydro-1,1,4,4-tetramethyl- (6683-46-1)

Safety information for 1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.