1,2-Di[(cis)-9-octadecenoyl]-sn-glycerol-3-phospho-[1-rac-glycerol] sodium salt

Description

1,2-Dioleoyl-sn-glycero-3-PG (DOPG) is a phospholipid containing the long-chain (18:1) fatty acid oleic acid inserted at the sn-1 and sn-2 positions. It can be used in the generation of micelles, liposomes, and other artificial membranes.

The Uses of 1,2-Di[(cis)-9-octadecenoyl]-sn-glycerol-3-phospho-[1-rac-glycerol] sodium salt

1,2-Dioleoyl-sn-glycero-3-phospho-rac-(1-glycerol) is an analog of 1,2-Dipalmitoyl-sn-glycero-3-phospho-rac-(1-glycerol) (D525495) which forms lipid bilayers. In the high temperature phase, the conformation of the chains is liquid-like. In the low temperature phases, the chains are stiff and parallel and they interdigitate.

The Uses of 1,2-Di[(cis)-9-octadecenoyl]-sn-glycerol-3-phospho-[1-rac-glycerol] sodium salt

18:1 (Δ9-Cis) PG has been used:

• in the preparation of giant unilamellar vesicle (GUV)
• in the preparation 200 nm large unilamellar vesicles (LUV)
• as a supplement in native macrophage membranes to generate membrane liposomes with an artificially modified electrical charge

What are the applications of Application

1,2-Dioleoyl-sn-glycero-3-phospho-rac-glycerol sodium salt is a lipid that has shown significant influence on SMR proteins

General Description

Phosphoglyceride (PG) are also referred as glycerophospholipid. It is an important component of membrane?bilayers. It has three-carbon backbone of glycerol, two long-chain?fatty acids,?esterified to?hydroxyl groups on carbons 1 and 2 of the glycerol and?phosphoric acid?esterified to the C3?hydroxyl group of glycerol. It is found at high levels in the membranes of all cells and at low levels in fat stores. 1,2-dioleoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (DOPG)/18:1 (Δ9-Cis) PG?has two hydroxyl groups in its head group. It is an anionic lipid.

Biochem/physiol Actions

Remodeling of diacylphosphatidylglycerols by transesterification was studied in a phosphatidylglycerol-deficient microbe grown with exogenous DOPG.