1,1,1-Trifluoroacetone

CAS NO.：421-50-1
Empirical Formula: C3H3F3O
Molecular Weight: 112.05
MDL number: MFCD00000423
EINECS: 207-005-9
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-25 17:15:13

What is 1,1,1-Trifluoroacetone?

Chemical properties

1,1,1-Trifluoroacetone is CLEAR COLOURLESS LIQUID

The Uses of 1,1,1-Trifluoroacetone

1,1,1-Trifluoroacetone is used as intermediate of bioactive substance and antihypertensive drug, and as effective synthetic building block and trifluoromethyl reaction reagent.

The Uses of 1,1,1-Trifluoroacetone

1,1,1-Trifluoroacetone is a general chemical reagent used in the synthesis of glucokinase-glucokinase regulatory protein) GK-GKRP disruptors which may act as potential targets for type II diabetics. Reactant for enantioselective cycloadditions.

The Uses of 1,1,1-Trifluoroacetone

Used in a synthesis of 2-trifluoromethyl-7-azaindoles starting with 2,6-dihalopyridines. The derived chiral imine was used to prepare enantiopure α-trifluoromethyl alanines and diamines via a Strecker reaction followed by either nitrile hydrolysis or reduction.

Properties of 1,1,1-Trifluoroacetone

Melting point:	-78 °C
Boiling point:	22 °C(lit.)
Density	1.252 g/mL at 25 °C(lit.)
vapor pressure	13.62 psi ( 20 °C)
refractive index	n20/D 1.3(lit.)
Flash point:	−23 °F
storage temp.	2-8°C
solubility	Chloroform, Methanol
form	Liquid
color	Clear colorless
Water Solubility	Miscible
Sensitive	Lachrymatory
BRN	1748614
Stability:	Volatile
CAS DataBase Reference	421-50-1(CAS DataBase Reference)
NIST Chemistry Reference	2-Propanone, 1,1,1-trifluoro-(421-50-1)
EPA Substance Registry System	2-Propanone, 1,1,1-trifluoro- (421-50-1)

Safety information for 1,1,1-Trifluoroacetone

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H224:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P403+P233:Store in a well-ventilated place. Keep container tightly closed.