1-NAPHTHOHYDROXAMIC ACID
Synonym(s):1-Naphthohydroxamic Acid, N-Hydroxynaphthalene-1-carboxamide, Histone Deacetylase Inhibitor XIX;a-Naphthohydroxamic acid;HDAC Inhibitor XIX, Compound 2 - CAS 6953-61-3 - Calbiochem;N-Hydroxynaphthalene-1-carboxamide;NSC 57457
- CAS NO.：6953-61-3
- Empirical Formula: C11H9NO2
- Molecular Weight: 187.19
- MDL number: MFCD00059546
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 00:33:53
What is 1-NAPHTHOHYDROXAMIC ACID?
The Uses of 1-NAPHTHOHYDROXAMIC ACID
1-Naphthohydroxamic Acid is a potent HDAC inhibitor with efficacy against HDAC8, HDAC1 and HDAC6.
What are the applications of Application
1-Naphthohydroxamic Acid is a potent HDAC inhibitor with efficacy against HDAC8, HDAC1 and HDAC6
Biochem/physiol Actions
1-Naphthohydroxamic Acid is a cell-permeable, potent, and selective histone deacetylase 8 (HDAC8) inhibitor. 1-Naphthohydroxamic acid selectively inhibits HDAC8 (IC50 = 14 μM) over class I HDAC1 and class II HDAC6 (IC50 >100 μM). Treatment of cells with 1-Naphthohydroxamic acid does not increase neither global histone H4 nor tubulin acetylation . Also in contrast to the pan-HDAC inhibitors the compound is not reducing total intracellular HDAC activity.
Properties of 1-NAPHTHOHYDROXAMIC ACID
| Melting point: | 176-178 °C |
| Density | 1.291±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥5mg/mL |
| pka | 8.91±0.30(Predicted) |
| form | White solid |
| color | white to tan |
Safety information for 1-NAPHTHOHYDROXAMIC ACID
Computed Descriptors for 1-NAPHTHOHYDROXAMIC ACID
New Products
Cis-Tosylate Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) 2,6-Dipicolic Acid 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One Dibenzo[b,f][1,4]thiazepin-11(10H)-one N-BOC-piperidine-4-carboxylic acid 1-Benzhydrylazetane-3-carbonitrile AMINO-(3-CHLORO-PHENYL)-ACETIC ACID 2-(2-Chlorophenyl)glycine (±)-amino(2-fluorophenyl)acetic acid 8-oxa-1,3-diazaspiro[4.5]decane-2,4-dione MEHYL AMINE-D3.HCL METHANE SULFONIC ACID-D4 PHOSPORIC ACID-D3 85 W% IN D2O DEUTERIUM OXIDE FOR NMR TOLUENE-D3 BENZENE-D6 1-(3-Chlorophenyl)piperazine hydrochlorideRelated products of tetrahydrofuran
You may like
-
1-Naphthohydroxamic Acid CAS 6953-61-3View Details
6953-61-3 -
7292-71-9 AMINO-(3-CHLORO-PHENYL)-ACETIC ACID 98+View Details
7292-71-9 -
84145-28-8 98+View Details
84145-28-8 -
2-(2-Chlorophenyl)glycine 98+View Details
88744-36-9 -
7292-71-9 AMINO-(3-CHLORO-PHENYL)-ACETIC ACID 98+View Details
7292-71-9 -
84145-28-8 98+View Details
84145-28-8 -
2-(2-Chlorophenyl)glycine 98+View Details
88744-36-9 -
8-oxa-1,3-diazaspiro[4.5]decane-2,4-dione 39124-19-1 98+View Details
39124-19-1
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.