1-NAPHTHOHYDROXAMIC ACID
Synonym(s):1-Naphthohydroxamic Acid, N-Hydroxynaphthalene-1-carboxamide, Histone Deacetylase Inhibitor XIX;a-Naphthohydroxamic acid;HDAC Inhibitor XIX, Compound 2 - CAS 6953-61-3 - Calbiochem;N-Hydroxynaphthalene-1-carboxamide;NSC 57457
- CAS NO.：6953-61-3
- Empirical Formula: C11H9NO2
- Molecular Weight: 187.19
- MDL number: MFCD00059546
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-07 19:09:50
What is 1-NAPHTHOHYDROXAMIC ACID?
The Uses of 1-NAPHTHOHYDROXAMIC ACID
1-Naphthohydroxamic Acid is a potent HDAC inhibitor with efficacy against HDAC8, HDAC1 and HDAC6.
What are the applications of Application
1-Naphthohydroxamic Acid is a potent HDAC inhibitor with efficacy against HDAC8, HDAC1 and HDAC6
Biochem/physiol Actions
1-Naphthohydroxamic Acid is a cell-permeable, potent, and selective histone deacetylase 8 (HDAC8) inhibitor. 1-Naphthohydroxamic acid selectively inhibits HDAC8 (IC50 = 14 μM) over class I HDAC1 and class II HDAC6 (IC50 >100 μM). Treatment of cells with 1-Naphthohydroxamic acid does not increase neither global histone H4 nor tubulin acetylation . Also in contrast to the pan-HDAC inhibitors the compound is not reducing total intracellular HDAC activity.
Properties of 1-NAPHTHOHYDROXAMIC ACID
| Melting point: | 176-178 °C |
| Density | 1.291±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥5mg/mL |
| pka | 8.91±0.30(Predicted) |
| form | White solid |
| color | white to tan |
Safety information for 1-NAPHTHOHYDROXAMIC ACID
Computed Descriptors for 1-NAPHTHOHYDROXAMIC ACID
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