1-Methylhistamine dihydrochloride
Synonym(s):1-Methyl-4-(β-aminoethyl)imidazole dihydrochloride
- CAS NO.：6481-48-7
- Empirical Formula: C6H13Cl2N3
- Molecular Weight: 198.09
- MDL number: MFCD00037000
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:54:56
What is 1-Methylhistamine dihydrochloride?
Description
1-Methylhistamine is a major metabolite of histamine by histamine N-methyltransferase in the pathway of histidine metabolism. It has been used as a biomarker of histaminergic system activity in the brains of Alzheimer’s disease patients as well as those with hypersomnia and other neurological conditions.
The Uses of 1-Methylhistamine dihydrochloride
1-Methylhistamine Dihydrochloride is a selective H1-receptor agonists. Also it has depressant effects.
Biochem/physiol Actions
Major metabolite of histamine by histamine N-methyltransferase.
Properties of 1-Methylhistamine dihydrochloride
| Melting point: | >198°C (dec.) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | powder |
| color | Pale Yellow |
| Stability: | Hygroscopic |
Safety information for 1-Methylhistamine dihydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-Methylhistamine dihydrochloride
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