1-Methyl-L-histidine
Synonym(s):Nτ-Methyl-L -histidine;3-(1-Methylimidazol-4-yl)-L -alanine;3-Methyl-L -histidine (archaic)
- CAS NO.：332-80-9
- Empirical Formula: C7H11N3O2
- Molecular Weight: 169.18
- MDL number: MFCD00005295
- EINECS: 206-368-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 15:00:32
What is 1-Methyl-L-histidine?
Chemical properties
Beige powder
The Uses of 1-Methyl-L-histidine
The urinary 1- and 3-methylhistidine (1- and 3-MH) metabolites as potential biomarkers of skeletal muscle toxicity. These metabolites were highly correlated to sex-, dose-, and time-dependent developm ent of cerivastatin-induced myotoxicity. Natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.
The Uses of 1-Methyl-L-histidine
The urinary 1- and 3-methylhistidine (1- and 3-MH) metabolites as potential biomarkers of skeletal muscle toxicity. These metabolites were highly correlated to sex-, dose-, and time-dependent development of cerivastatin-induced myotoxicity. Natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.
Definition
ChEBI: N(tele)-methyl-L-histidine is a L-histidine derivative in which the methyl group is at N(tele)-position. It has a role as a human metabolite. It is a L-histidine derivative and a non-proteinogenic L-alpha-amino acid. It is a tautomer of a N(tele)-methyl-L-histidine zwitterion.
Properties of 1-Methyl-L-histidine
| Melting point: | ~240 °C (dec.) (lit.) |
| Boiling point: | 298.47°C (rough estimate) |
| alpha | -24 º (c=2% in H2O) |
| Density | 1.2509 (rough estimate) |
| refractive index | 1.5950 (estimate) |
| storage temp. | 2-8°C(protect from light) |
| solubility | Methanol (Slightly), Water (Slightly, Sonicated) |
| form | Solid |
| pka | 1.69(at 25℃) |
| color | Off-White to Pale Beige |
| optical activity | [α]20/D 24±1°, c = 2% in H2O |
| BRN | 9727 |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 332-80-9(CAS DataBase Reference) |
Safety information for 1-Methyl-L-histidine
Computed Descriptors for 1-Methyl-L-histidine
New Products
2-(3-Methyl-1,2,4-oxadiazol-5-yl)acetic acid (as potassium salt) 2-fluoro-4-iodoaniline 4-Iodo-3,5-dimethylbenzonitrile Atorvastatin amide impurity/Atorvastatin EP Impurity F(Calcium Salt) Lantanoprost rc B Clidinium Bromide Impurity Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity N-Nitroso hydroxy Cetrizine EP Impurity-A (4-Fluoro-2-methoxy-5-nitro- phenyl)-[4- (1-methyl-1H- indol-3- yl)-pyrimidin-2-yl]- amine 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole tert-butyl 4-(6-((7-cyclo pentyl -6-(dimethyl carbamoyl) -7H-pyrrolo [2,3-d]pyrimidin-2-yl) amino)pyridin-3-yl) piperazine-1-carboxylate 2-Fluoro-4-nitrotoluene 1-(2-amino-5-hydroxy phenyl)propan-1-one (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3- amine 3-(Dimethylamino)benzoic acid 2-Amino-5-chloropyridine 4-(Methylamino)-3-nitrobenzoic Acid 5-Chloro-2-Nitroaniline 3,5-dibenzyloxy Acetophenone 2,4-Diamino-6-hydroxypyrimidine 2-Chloro Benzylcyanide 3-chlorobenzyl cyanide 3,4 Diethoxy BenzylcyanideRelated products of tetrahydrofuran
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