1-Methyl-L-histidine
Synonym(s):Nτ-Methyl-L -histidine;3-(1-Methylimidazol-4-yl)-L -alanine;3-Methyl-L -histidine (archaic)
- CAS NO.：332-80-9
- Empirical Formula: C7H11N3O2
- Molecular Weight: 169.18
- MDL number: MFCD00005295
- EINECS: 206-368-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-11 15:21:01
What is 1-Methyl-L-histidine?
Chemical properties
Beige powder
The Uses of 1-Methyl-L-histidine
The urinary 1- and 3-methylhistidine (1- and 3-MH) metabolites as potential biomarkers of skeletal muscle toxicity. These metabolites were highly correlated to sex-, dose-, and time-dependent developm ent of cerivastatin-induced myotoxicity. Natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.
The Uses of 1-Methyl-L-histidine
The urinary 1- and 3-methylhistidine (1- and 3-MH) metabolites as potential biomarkers of skeletal muscle toxicity. These metabolites were highly correlated to sex-, dose-, and time-dependent development of cerivastatin-induced myotoxicity. Natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.
Definition
ChEBI: N(tele)-methyl-L-histidine is a L-histidine derivative in which the methyl group is at N(tele)-position. It has a role as a human metabolite. It is a L-histidine derivative and a non-proteinogenic L-alpha-amino acid. It is a tautomer of a N(tele)-methyl-L-histidine zwitterion.
Properties of 1-Methyl-L-histidine
| Melting point: | ~240 °C (dec.) (lit.) |
| Boiling point: | 298.47°C (rough estimate) |
| alpha | -24 º (c=2% in H2O) |
| Density | 1.2509 (rough estimate) |
| refractive index | 1.5950 (estimate) |
| storage temp. | 2-8°C(protect from light) |
| solubility | Methanol (Slightly), Water (Slightly, Sonicated) |
| form | Solid |
| pka | 1.69(at 25℃) |
| color | Off-White to Pale Beige |
| optical activity | [α]20/D 24±1°, c = 2% in H2O |
| BRN | 9727 |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 332-80-9(CAS DataBase Reference) |
Safety information for 1-Methyl-L-histidine
Computed Descriptors for 1-Methyl-L-histidine
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