1-Methyl-L-histidine
Synonym(s):Nτ-Methyl-L -histidine;3-(1-Methylimidazol-4-yl)-L -alanine;3-Methyl-L -histidine (archaic)
- CAS NO.：332-80-9
- Empirical Formula: C7H11N3O2
- Molecular Weight: 169.18
- MDL number: MFCD00005295
- EINECS: 206-368-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:24:42
What is 1-Methyl-L-histidine?
Chemical properties
Beige powder
The Uses of 1-Methyl-L-histidine
The urinary 1- and 3-methylhistidine (1- and 3-MH) metabolites as potential biomarkers of skeletal muscle toxicity. These metabolites were highly correlated to sex-, dose-, and time-dependent developm ent of cerivastatin-induced myotoxicity. Natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.
The Uses of 1-Methyl-L-histidine
The urinary 1- and 3-methylhistidine (1- and 3-MH) metabolites as potential biomarkers of skeletal muscle toxicity. These metabolites were highly correlated to sex-, dose-, and time-dependent development of cerivastatin-induced myotoxicity. Natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.
Definition
ChEBI: N(tele)-methyl-L-histidine is a L-histidine derivative in which the methyl group is at N(tele)-position. It has a role as a human metabolite. It is a L-histidine derivative and a non-proteinogenic L-alpha-amino acid. It is a tautomer of a N(tele)-methyl-L-histidine zwitterion.
Properties of 1-Methyl-L-histidine
| Melting point: | ~240 °C (dec.) (lit.) |
| Boiling point: | 298.47°C (rough estimate) |
| alpha | -24 º (c=2% in H2O) |
| Density | 1.2509 (rough estimate) |
| refractive index | 1.5950 (estimate) |
| storage temp. | 2-8°C(protect from light) |
| solubility | Methanol (Slightly), Water (Slightly, Sonicated) |
| form | Solid |
| pka | 1.69(at 25℃) |
| color | Off-White to Pale Beige |
| optical activity | [α]20/D 24±1°, c = 2% in H2O |
| BRN | 9727 |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 332-80-9(CAS DataBase Reference) |
Safety information for 1-Methyl-L-histidine
Computed Descriptors for 1-Methyl-L-histidine
New Products
Levothyroxine Impurity-F Montelukast EP Impurity-D/Montelukast USP Related Compound C Atorvastatin FXA Impurity/Atorvastatin Cyclic 6-Hydroxy Impurity Sodium Salt Isosulfan blue Keto N-Oxide Impurity Ivermectin Impurity F N-Nitroso des Methyl Tramadol/N-Nitroso-N-Desmethyl-Tramadol DL-beta-(3-Bromophenyl)alanine Tetrabutylammonium perchlorate N,O-Dimethylhydroxylamine hydrochloride (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid 2-Amino-5-bromo-4-(trifluoromethyl)pyridine（RM for Indian lab) N,N CARBONYL DIIMIDAZOLE (R)-BoroLeu-(+)-Pinanediol-CF3COOH 1,4-bis(methylsulfonyl)butane 4-(5-amino-1-methyl-1h-benzoimidazol-2-yl)-butyric acid isopropyl ester. 5-Methyl-1,3-benzenediacetonitrile 4-Fluorothiophenol 1-methyl amino-2,4-dinitro benzene CSA (DL-10-Camphorsulfonic Acid) 2-Hydroxy-4-methylnicotinic acid 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine (2S)-1-((2S,3S)-3-(2-methylbutyl)-4-oxooxetan-2-yl)pentadecan-2-yl formylleucinate 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethane-1-sulfonyl chloride S-(1-(3,5-dichlorophenyl)-2,2,2-trifluoroethyl) ethanethioateRelated products of tetrahydrofuran
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