1-Methyl-L-histidine

Synonym(s):N_τ-Methyl-L-histidine;3-(1-Methylimidazol-4-yl)-L-alanine;3-Methyl-L-histidine (archaic)

CAS NO.：332-80-9
Empirical Formula: C7H11N3O2
Molecular Weight: 169.18
MDL number: MFCD00005295
EINECS: 206-368-0
SAFETY DATA SHEET (SDS)
Update Date: 2025-11-05 08:34:14

What is 1-Methyl-L-histidine?

Chemical properties

Beige powder

The Uses of 1-Methyl-L-histidine

The urinary 1- and 3-methylhistidine (1- and 3-MH) metabolites as potential biomarkers of skeletal muscle toxicity. These metabolites were highly correlated to sex-, dose-, and time-dependent developm ent of cerivastatin-induced myotoxicity. Natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.

The Uses of 1-Methyl-L-histidine

The urinary 1- and 3-methylhistidine (1- and 3-MH) metabolites as potential biomarkers of skeletal muscle toxicity. These metabolites were highly correlated to sex-, dose-, and time-dependent development of cerivastatin-induced myotoxicity. Natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.

Definition

ChEBI: N(tele)-methyl-L-histidine is a L-histidine derivative in which the methyl group is at N(tele)-position. It has a role as a human metabolite. It is a L-histidine derivative and a non-proteinogenic L-alpha-amino acid. It is a tautomer of a N(tele)-methyl-L-histidine zwitterion.

Properties of 1-Methyl-L-histidine

Melting point:	~240 °C (dec.) (lit.)
Boiling point:	298.47°C (rough estimate)
alpha	-24 º (c=2% in H2O)
Density	1.2509 (rough estimate)
refractive index	1.5950 (estimate)
storage temp.	2-8°C(protect from light)
solubility	Methanol (Slightly), Water (Slightly, Sonicated)
form	Solid
pka	1.69(at 25℃)
color	Off-White to Pale Beige
optical activity	[α]20/D 24±1°, c = 2% in H2O
BRN	9727
Stability:	Hygroscopic
CAS DataBase Reference	332-80-9(CAS DataBase Reference)