3-Methyl-L-histidine
Synonym(s):π-Methyl-L -histidine;1-Methyl-L -histidine (archaic);3-(1-Methylimidazol-5-yl)-L -alanine
- CAS NO.：368-16-1
- Empirical Formula: C7H11N3O2
- Molecular Weight: 169.18
- MDL number: MFCD08273564
- EINECS: 206-704-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:56:20
What is 3-Methyl-L-histidine?
Chemical properties
White to off-white powder
The Uses of 3-Methyl-L-histidine
3-Methyl-L-histidine is a potential compound to be used as a treatment with pharmacological PPARα agonists to stimulate the ubiquitin proteasome pathway and myofibrillar protein breakdown in skeleta l muscle of rodents.
Definition
ChEBI: A L-histidine derivative that is L-histidine substituted by a methyl group at position 3 on the imidazole ring.
Biochem/physiol Actions
3-Methyl-L-histidine is a non-proteinogenic amino acid and an index of muscle breakdown.
Properties of 3-Methyl-L-histidine
| Melting point: | 248～252℃ |
| Boiling point: | 298.47°C (rough estimate) |
| alpha | +12.0～+18.0°(20℃/D)(c=2,dil.HCl) |
| Density | 1.37 |
| refractive index | 1.5950 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | PBS (pH 7.2): 10 mg/ml |
| form | A crystalline solid |
| pka | 2.04±0.10(Predicted) |
| color | White to off-white |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 368-16-1(CAS DataBase Reference) |
Safety information for 3-Methyl-L-histidine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-Methyl-L-histidine
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