1-Cyclohexylpiperidine
- CAS NO.：3319-01-5
- Empirical Formula: C11H21N
- Molecular Weight: 167.29
- MDL number: MFCD00014642
- EINECS: 222-016-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:54:24
What is 1-Cyclohexylpiperidine?
The Uses of 1-Cyclohexylpiperidine
1-Cyclohexylpiperidine is used in the preparation of 1-(1-phenylcyclohexyl)piperidine, which shows anticholinesterase activity and antagonistic activity to acetylcholine. It is used as a N-methyl-D-aspartate receptor (NMDAR) antagonist. Further, it is used as an anesthetic for animals.
Definition
ChEBI: N-cyclohexylpiperidine is a member of piperidines.
Synthesis Reference(s)
Journal of the American Chemical Society, 72, p. 1597, 1950 DOI: 10.1021/ja01160a046
Tetrahedron, 52, p. 10835, 1996 DOI: 10.1016/0040-4020(96)00631-X
Properties of 1-Cyclohexylpiperidine
| Melting point: | 73-74 °C(Solv: benzene (71-43-2); ligroine (8032-32-4)(1:5)) |
| Boiling point: | 231-234°C |
| Density | 0,914 g/cm3 |
| refractive index | 1.4856 |
| Flash point: | 231-234°C |
| form | clear liquid |
| pka | 10.07±0.20(Predicted) |
| color | Colorless to Light yellow |
| Water Solubility | Immiscible with water. |
| BRN | 105594 |
Safety information for 1-Cyclohexylpiperidine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 1-Cyclohexylpiperidine
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