1-CYCLOHEXYLPIPERIDINE

CAS NO.：3319-01-5
Empirical Formula: C11H21N
Molecular Weight: 167.29
MDL number: MFCD00014642
EINECS: 222-016-9
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 04:39:37

What is 1-CYCLOHEXYLPIPERIDINE?

The Uses of 1-CYCLOHEXYLPIPERIDINE

1-Cyclohexylpiperidine is used in the preparation of 1-(1-phenylcyclohexyl)piperidine, which shows anticholinesterase activity and antagonistic activity to acetylcholine. It is used as a N-methyl-D-aspartate receptor (NMDAR) antagonist. Further, it is used as an anesthetic for animals.

Definition

ChEBI: N-cyclohexylpiperidine is a member of piperidines.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 1597, 1950 DOI: 10.1021/ja01160a046
Tetrahedron, 52, p. 10835, 1996 DOI: 10.1016/0040-4020(96)00631-X

Properties of 1-CYCLOHEXYLPIPERIDINE

Melting point:	73-74 °C(Solv: benzene (71-43-2); ligroine (8032-32-4)(1:5))
Boiling point:	231-234°C
Density	0,914 g/cm³
refractive index	1.4856
Flash point:	231-234°C
form	clear liquid
pka	10.07±0.20(Predicted)
color	Colorless to Light yellow
Water Solubility	Immiscible with water.
BRN	105594

Safety information for 1-CYCLOHEXYLPIPERIDINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.