1-Chloro-N,N,2-trimethylpropenylamine
Synonym(s):Ghosez′s reagent
- CAS NO.：26189-59-3
- Empirical Formula: C6H12ClN
- Molecular Weight: 133.62
- MDL number: MFCD00800562
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-09-25 17:15:13
What is 1-Chloro-N,N,2-trimethylpropenylamine?
Chemical properties
Colorless to yellow liquid
The Uses of 1-Chloro-N,N,2-trimethylpropenylamine
1-Chloro-N,N,2-trimethyl-1-propenylamine is an acid halogenation reagent developed by Ghosez, that enables the conversion of carboxylic acids into the corresponding chlorides under strictly neutral conditions. This method was successfully used in the total synthesis of caloporoside, roseophilin, (-)-enniatin B, (±)-epimeloscine and (±)-meloscine.
What are the applications of Application
1-Chloro-N,N,2-trimethyl-1-propenylamine is used in the conversion of carboxylic acids to acid chloride
Synthesis Reference(s)
Journal of the American Chemical Society, 94, p. 2869, 1972 DOI: 10.1021/ja00763a061
Organic Syntheses, Coll. Vol. 6, p. 282, 1988
Tetrahedron Letters, 25, p. 5043, 1984 DOI: 10.1016/S0040-4039(01)91114-1
Properties of 1-Chloro-N,N,2-trimethylpropenylamine
| Boiling point: | 129-130 °C(lit.) |
| Density | 1.01 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 80 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| pka | 4.27±0.70(Predicted) |
| form | Liquid |
| color | Colorless to yellow |
| Stability: | Hygroscopic, Moisture Sensitive, Unstable in Solution |
Safety information for 1-Chloro-N,N,2-trimethylpropenylamine
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H226:Flammable liquids H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-Chloro-N,N,2-trimethylpropenylamine
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