1-Bromo-2,4-difluorobenzene
- CAS NO.：348-57-2
- Empirical Formula: C6H3BrF2
- Molecular Weight: 192.99
- MDL number: MFCD00000330
- EINECS: 206-479-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 01:03:16
What is 1-Bromo-2,4-difluorobenzene?
Chemical properties
Clear colorless to brown liqui
The Uses of 1-Bromo-2,4-difluorobenzene
1-Bromo-2,4-difluorobenzene has been used in:
- preparation of (2S)-1-(2,4-difluorophenyl)-2-(1,1-dimethyl-1-sila-ethoxy)-propan-1-one
- enantiomeric preparation of the key intermediate of chiral azole antifungal agents by a chemoenzymatic process
General Description
1-Bromo-2,4-difluorobenzene undergoes lithiation exclusively at the position having two adjacent halogen substituents, to yield 6-bromo-2,3-difluorobenzoic acid.
Properties of 1-Bromo-2,4-difluorobenzene
| Melting point: | -4 °C (lit.) |
| Boiling point: | 145-146 °C (lit.) |
| Density | 1.708 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 125 °F |
| storage temp. | Sealed in dry,2-8°C |
| form | Liquid |
| color | Clear colorless to brown |
| Specific Gravity | 1.708 |
| PH | 5.02 at 24℃ and 10g/L |
| Water Solubility | INSOLUBLE |
| BRN | 1680892 |
| CAS DataBase Reference | 348-57-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzene, 1-bromo-2,4-difluoro-(348-57-2) |
Safety information for 1-Bromo-2,4-difluorobenzene
| Signal word | Warning |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-Bromo-2,4-difluorobenzene
| InChIKey | MGHBDQZXPCTTIH-UHFFFAOYSA-N |
1-Bromo-2,4-difluorobenzene manufacturer
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