1,2-Difluorobenzene

CAS NO.：367-11-3
Empirical Formula: C6H4F2
Molecular Weight: 114.09
MDL number: MFCD00000284
EINECS: 206-680-7
SAFETY DATA SHEET (SDS)
Update Date: 2026-06-23 16:59:16

What is 1,2-Difluorobenzene?

Chemical properties

colourless liquid

The Uses of 1,2-Difluorobenzene

1,2-Difluorobenzene is used in electrochemical analysis of transition metal complexes. 1,2-difluorobenzene is also a potent inhibitor of NMDA receptor.

The Uses of 1,2-Difluorobenzene

1,2-Difluorobenzene(1,2-DFB) has been used to study the mechanism of dissociation of o-, m- and p-difluorobenzene ions by threshold photoelectron photoion coincidence spectroscopy. It has been used to study the room temperature adsorption of 1,2-DFB, 1,2-dichlorobenzene and 1,2-dibromobenzene on Si(100)2x1 by X-ray photoelectron spectroscopy and temperature programmed desorption. It is used as solvent in electrochemical studies on transition metal complexes. It is also applied as a solvent useful for electrochemical studies on transition metal complexes.

Definition

ChEBI: A difluorobenzene carrying fluoro groups at positions 1 and 2.

General Description

1,2-Difluorobenzene undergoes defluorination under very mild conditions by H₂ in the presence of NaOAc over rhodium pyridylphosphine and bipyridyl complexes tethered on a silica-supported palladium catalyst.

Properties of 1,2-Difluorobenzene

Melting point:	−34 °C(lit.)
Boiling point:	92 °C(lit.)
Density	1.158 g/mL at 25 °C(lit.)
refractive index	n20/D 1.443(lit.)
Flash point:	36 °F
storage temp.	Flammables area
solubility	Chloroform, Methanol
form	Liquid
color	Clear colorless
Specific Gravity	1.158
Water Solubility	Not miscible or difficult to mix in water.
BRN	1905113
Dielectric constant	14.26
Stability:	Stable. Incompatible with strong oxidizing agents. Highly flammable. Note low flash point.
CAS DataBase Reference	367-11-3(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 1,2-difluoro-(367-11-3)
EPA Substance Registry System	Benzene, 1,2-difluoro- (367-11-3)

Safety information for 1,2-Difluorobenzene

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02
GHS Hazard Statements	H225:Flammable liquids
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.