2,4-Difluorophenol
- CAS NO.：367-27-1
- Empirical Formula: C6H4F2O
- Molecular Weight: 130.09
- MDL number: MFCD00009715
- EINECS: 206-688-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:17:35
What is 2,4-Difluorophenol?
Chemical properties
clear yellow-green liquid after melting
The Uses of 2,4-Difluorophenol
2,4-Difluorophenol, is an organic building block used for the synthesis of various pharmaceutical compounds, such as antivirulence agents. It is also used in the synthesis of new α-Phenoxyacetamide derivatives, acting as type III secretion system of Pseudomonas aeruginosa PAO1, a gram-negative bacteria.
The Uses of 2,4-Difluorophenol
2,4-Difluorophenol has been used:
- as starting reagent during the synthesis of 4,6-difluoro-5,7-dihydroxytryptamine
- in the synthesis of 3-carboxy-6,8-difluoro-7-hydroxycoumarin (Pacific Blue), fluorinated fluorescent dye
Properties of 2,4-Difluorophenol
| Melting point: | 22.4 °C (lit.) |
| Boiling point: | 52-53 °C/19 mmHg (lit.) |
| Density | 1.362 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 134 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| form | powder to lump to clear liquid |
| pka | 8.72±0.18(Predicted) |
| Specific Gravity | 1.362 |
| color | White or Colorless to Yellow |
| Water Solubility | slightly soluble |
| BRN | 1934803 |
| CAS DataBase Reference | 367-27-1(CAS DataBase Reference) |
| NIST Chemistry Reference | 2,4-Difluorophenol(367-27-1) |
Safety information for 2,4-Difluorophenol
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2,4-Difluorophenol
| InChIKey | NVWVWEWVLBKPSM-UHFFFAOYSA-N |
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