1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE
Synonym(s):1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate;VUF 6002 maleate;VUF6002 maleate
- CAS NO.：869497-75-6
- Empirical Formula: C17H19ClN4O5
- Molecular Weight: 394.80956
- MDL number: MFCD08703121
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-09 17:14:16
![1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE Structural](https://img.chemicalbook.in/CAS/GIF/869497-75-6.gif)
What is 1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE?
The Uses of 1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE
A highly selective histamine H4 receptor silent antagonist
What are the applications of Application
JNJ 10191584 maleate is a selective histamine H4 receptor silent antagonist
Biological Activity
Highly selective histamine H 4 receptor silent antagonist; binds with high affinity to the human H 4 receptor (K i = 26 nM) and is > 540-fold selective over the H 3 receptor (K i = 14.1 μ M). In vitro, inhibits mast cell and eosinophil chemotaxis with IC 50 values of 138 and 530 nM respectively. Orally active in vivo .
Storage
room temperature (desiccate)
Properties of 1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE
| storage temp. | Desiccate at RT |
| solubility | DMSO: ≥10mg/mL |
| form | powder |
| color | off-white to light tan |
Safety information for 1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE
New Products
4,4-Difluoropiperidine hydrochloride tert-butyl 9-methoxy-3-azaspiro[5.5]undecane-3-carboxylate Indole Methyl Resin N-Isopropylurea N,N-Dicyclohexylcarbodiimide(DCC) MELDRUMS ACID 5-METHYLISOXAZOLE-4-CARBOXYLIC ACID Magnessium Bis glycinate Zinc ascorbate 1-bromo-2-butyne 2-acetamidophenol 9(10H)-anthracenone Erythrosin B, 4-Piperidinopiperidine 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile 2,4-dihydroxybenzaldehyde 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile Methyl 2-methylquinoline-6-carboxylate 2,6-dichloro-4-nitropyridine 4-Bromo-2-chlorobenzonitrile 2-(benzylamino)acetic acid hydrochloride 4-(tert-Butoxycarbonylamino)but- 2-ynoic acid 3,4-dihydro-2H-benzo[b][1,4]dioxepine 1-Phenyl-1-cycloprppanecarboxylicacidRelated products of tetrahydrofuran
You may like
-
3-(4-amino-1-oxoisoindolin-2-yl)-1-methylpiperidine-2,6-dione 98%View Details -
1-methylindoline-2,3-dione 98%View Details
2058-74-4 -
614-19-7 98%View Details
614-19-7 -
3112-85-4 Methyl phenyl sulfone 98%View Details
3112-85-4 -
20677-73-0 (2,2-diethoxyethyl)methylamine 98%View Details
20677-73-0 -
3-(4-(hydroxyamino)-1-oxoisoindolin-2-yl)piperidine-2,6-dione 98%View Details
-
57381-49-4 2-bromo-4-chlorobenzonitrile 98%View Details
57381-49-4 -
4,6-dichloropyrimidine-5-carbaldehyde 98%View Details
5305-40-8
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.