1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride
Synonym(s):1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride
- CAS NO.：85375-15-1
- Empirical Formula: C22H26ClNO2
- Molecular Weight: 371.9
- MDL number: MFCD01321071
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:54:44
What is 1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride?
The Uses of 1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride
SKF-89976A is a GABA transporters (GATs) type 1 inhibitor.
What are the applications of Application
SKF-89976A is a GABA transporter type 1 inhibitor
Biological Activity
A potent GABA uptake inhibitor, selective for GAT-1 (IC 50 values are 0.13, 550, 944 and 7210 μ M for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Inhibits transport current competitively (K i = 7 μ M) and transmitter-gated current non-competitively (K i = 0.03 nM). Able to pass the blood-brain barrier after systemic administration and is active in vivo .
Storage
+4°C (desiccate)
Properties of 1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO: 20 mg/mL, soluble |
| form | solid |
| color | white |
Safety information for 1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride
Computed Descriptors for 1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride
New Products
5-bromo-4-fluoro-2-nitrobenzaldehyde Cyclobutanone (R)-(-)-2-Amino-1-propanol Fmoc-OSu 1-(2-Chloroethyl)pyrrolidine Hydrochloride 2-Amino-2-(4-methylphenyl)acetic acid 2,4-Dihydroxybenzaldehyde Obidoxime hydrochloride API Pyrrolo[1,2-a]pyrimidine-6-carboxylic acid, 4,6,7,8-tetrahydro-4-oxo-, sodium salt (1:1), (6S) Dipropyl disulfide 4 pentyn 1 ol N-Vinylformamide Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 2-Butyn-1-oL 2-Pentyn-1-oL 4-Nitrobenzotrifluoride N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamide N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd.Related products of tetrahydrofuran
You may like
-
7250-67-1 1-(2-Chloroethyl)pyrrolidine Hydrochloride 98+View Details
7250-67-1 -
7250-67-1 1-(2-Chloroethyl)pyrrolidine Hydrochloride 98+View Details
7250-67-1 -
13227-01-5 98+View Details
13227-01-5 -
545445-44-1 3-Morpholino-1-(4-(2-oxopiperidin-1-yl) phenyl)-5,6-dihyropyridin-2-(1H)-one 98%View Details
545445-44-1 -
6629-04-5 98%View Details
6629-04-5 -
4-(4-Αminophenyl)-3-Morpholinone 98%View Details
438056-69-0 -
1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one 1267610-26-3 98%View Details
1267610-26-3 -
1H-Indazole | CAS No. 271-44-3 | Pharmaceutical IntermediateView Details
271-44-3
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.