(+/-)-(R,R)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM

CAS NO.：127299-93-8
Empirical Formula: C19H23ClNNaO4
Molecular Weight: 387.84
MDL number: MFCD09971030
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:19:16

What is (+/-)-(R,R)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM?

The Uses of (+/-)-(R,R)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM

BRL 37344 Sodium is a potent and selective b3-AR agonist.

What are the applications of Application

BRL-37344 is a potent and selective β3-AR agonist

Biological Activity

Potent and selective β 3 adrenoceptor agonist (K i values are 287, 1750 and 1120 nM for β 3 , β 1 and β 2 receptors respectively). Also available as part of the β -Adrenoceptor Agonist Tocriset™ .

Biochem/physiol Actions

BRL 37344 is a selective β3-adrenoceptor agonist. Studies support the hypothesis that there are peripheral β3 adrenergic receptors that can reduce food intake and that central β2 or β3 adrenergic receptors mediate the peripheral effects of the β3 agonist.

Storage

Store at RT

References

[1]. simard pm, atgié c, mauriège p, et al. comparison of the lipolytic effects of norepinephrine and brl 37344 in rat brown and white adipocytes. obes res, 1994, 2(5): 424-431.
[2]. kozlovski vi, chlopicki s, gryglewski rj. effects of two beta3-agonists, cgp 12177a and brl 37344, on coronary flow and contractility in isolated guinea pig heart. j cardiovasc pharmacol, 2003, 41(5): 706-713.
[3]. reverte m, rivas-cabañero l. effects of the beta 3-adrenoceptor agonist brl 37344 on lipomobilization and plasma glucose levels in conscious fasted rabbits. can j physiol pharmacol, 1996, 74(3): 251-256.
[4]. kasahara h, muto s, motokawa y, et al. β3-adrenoceptor-mediated increased circulating transaminase levels in mice treated with its agonist brl 37344. j toxicol sci, 2010, 35(5): 779-784.

Properties of (+/-)-(R,R)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM

storage temp.	Store at RT
solubility	H₂O: 10 mg/mL
form	powder
color	white
Water Solubility	Soluble to 100 mM in water

Safety information for (+/-)-(R,R)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM

Computed Descriptors for (+/-)-(R,R)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM

New Products

Levothyroxine Impurity-F Montelukast EP Impurity-D/Montelukast USP Related Compound C Atorvastatin FXA Impurity/Atorvastatin Cyclic 6-Hydroxy Impurity Sodium Salt Isosulfan blue Keto N-Oxide Impurity Ivermectin Impurity F N-Nitroso des Methyl Tramadol/N-Nitroso-N-Desmethyl-Tramadol DL-beta-(3-Bromophenyl)alanine Tetrabutylammonium perchlorate N,O-Dimethylhydroxylamine hydrochloride (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid 2-Amino-5-bromo-4-(trifluoromethyl)pyridine（RM for Indian lab) N,N CARBONYL DIIMIDAZOLE (R)-BoroLeu-(+)-Pinanediol-CF3COOH 1,4-bis(methylsulfonyl)butane 4-(5-amino-1-methyl-1h-benzoimidazol-2-yl)-butyric acid isopropyl ester. 5-Methyl-1,3-benzenediacetonitrile 4-Fluorothiophenol 1-methyl amino-2,4-dinitro benzene CSA (DL-10-Camphorsulfonic Acid) 2-Hydroxy-4-methylnicotinic acid 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine (2S)-1-((2S,3S)-3-(2-methylbutyl)-4-oxooxetan-2-yl)pentadecan-2-yl formylleucinate 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethane-1-sulfonyl chloride S-(1-(3,5-dichlorophenyl)-2,2,2-trifluoroethyl) ethanethioate

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Phenoxyacetic acid sodium salt

Phenoxyacetic acid