(+)-Bis[(R)-1-phenylethyl]amine

Synonym(s):(+)-Bis[(R)-α-methylbenzyl]amine;[R-(R,R)]-(+)-Bis(α-methylbenzyl)amine

(+)-Bis[(R)-1-phenylethyl]amine play a very extensive role of making chirally optically active drugs and compounds. Also as intermediates.

(+)-Bis[(R)-1-phenylethyl]amine can be used:

In the synthesis of?β-amino acids.
In the preparation of chiral C(19)-C(26) and C(27)-C(32) moieties of scytophycin C.
To induce enantioselectivity in the deprotonation of prochiral ketones.
As a starting material for the synthesis of chiral phenolate ligands through Mannich condensation reaction.
In the synthesis of chiral phosphoramidite ligands.
To prepare chiral cyclic isoimidium salts, which are further used to synthesize chiral lactones through Diels-Alder reaction.

Melting point:	~260 °C
Boiling point:	86 °C0.05 mm Hg(lit.)
alpha	199 º (NEAT)
Density	0.985 g/mL at 25 °C(lit.)
refractive index	n20/D 1.5523(lit.)
Flash point:	>230 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	8.79±0.29(Predicted)
optical activity	[α]20/D +199.0°, neat
Water Solubility	Insoluble in water.
BRN	3590931
CAS DataBase Reference	23294-41-9

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.