(+)-AEROPLYSININ-1
- CAS NO.：28656-91-9
- Empirical Formula: C9H9Br2NO3
- Molecular Weight: 338.98
- MDL number: MFCD01745659
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-08-20 16:56:23
What is (+)-AEROPLYSININ-1?
Description
(+)-Aeroplysinin-1 is a metabolite originally isolated from the marine sponge V. aerophoba with diverse biological activities. (+)-Aeroplysinin-1 (0.25-0.5 μM) induces cell death in MCF-7 and ZR-75-1 human breast cancer cells in a time- and concentration-dependent manner but has no effect on normal human fibroblasts at concentrations up to 5 μM. It also blocks EGF-induced endocytosis of the EGF receptor (EGFR) and EGF-dependent cell proliferation in MCF-7 cells. (+)-Aeroplysinin-1 inhibits bovine aortic endothelial (BAE) cell proliferation and cord formation in a Matrigel™ assay. It inhibits angiogenesis in a dose-dependent manner in a chick chorioallantoic membrane (CAM) assay when administered from 1.5 to 3 nmol per egg. (+)-Aeroplysinin-1 also has antibacterial activity against Gram-positive bacteria, including S. aureus, S. albus, and B. subtilis, but not Gram-negative bacteria and inhibits HIV-1 replication (IC50 = 14.6 μM) via inhibition of HIV-1 reverse transcriptase.
The Uses of (+)-AEROPLYSININ-1
(+)shy-Aeroplysinin-1 is a compound that is an inhibitor of EGFR kinase.
What are the applications of Application
(+)-Aeroplysinin-1 is a compound that is an inhibitor of EGFR kinase
Definition
ChEBI: Aeroplysinin 1 is a tertiary alcohol.
Properties of (+)-AEROPLYSININ-1
| Boiling point: | 479.6±45.0 °C(Predicted) |
| Density | 2.01±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Methanol: Soluble |
| form | A solid |
| pka | 10.54±0.70(Predicted) |
| color | Colorless to off-white |
Safety information for (+)-AEROPLYSININ-1
Computed Descriptors for (+)-AEROPLYSININ-1
New Products
4-Iodo-3,5-dimethylbenzonitrile 2-fluoro-4-iodoaniline 2-(3-Methyl-1,2,4-oxadiazol-5-yl)acetic acid (as potassium salt) 6,6'-methylenebis(9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-2,3-dihydro-1H-carbazol-4(9H)-one) 3-Bromo-2-fluorobenzoic acid Quinuclidine-4-carbonitrile N,N CARBONYL DIIMIDAZOLE 2-Amino-5-bromo-4-(trifluoromethyl)pyridine（RM for Indian lab) (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid Tetrabutylammonium perchlorate N,O-Dimethylhydroxylamine hydrochloride (R)-1-Benzyl-3-pyrrolidinecarbonitrile Bupropian related compound F Lantanoprost rc B Clidinium Bromide Impurity Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity N-Nitroso hydroxy Cetrizine EP Impurity-A 4-(5-amino-1-methyl-1h-benzoimidazol-2-yl)-butyric acid isopropyl ester. 1,4-bis(methylsulfonyl)butane 4-Cyano-N-Methacryloyl-3-Trifluoromethyl Aniline 5-Methyl-1,3-benzenediacetonitrile 4-Fluorothiophenol 1-methyl amino-2,4-dinitro benzeneRelated products of tetrahydrofuran
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