(+)-1,2-Bis((2S,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium(l)tetrafluoroborate

Chemical properties

Dark orange-red solid

The Uses of (+)-1,2-Bis((2S,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium(l)tetrafluoroborate

DuPhos and BPE Ligands: Highly Efficient Privileged Ligands

Catalyst for:

• Preparation of a key unit B precursor of cryptophycins via Horner-Wadsworth-Emmons reaction and asymmetric hydrogenation
• Preparation of constrained phenylalanine analogs via Heck reaction followed by asymmetric hydrogenation and cyclization steps
• Enantioselective preparation of N-benzyloxy-β-amino acid Me esters by hydrogenation of α-(benzyloxyaminomethyl)acrylate stereoisomers
• Preparation of fluoro amino acids as synthons for potent macrocyclic HCV NS3 protease inhibitors
• Stereoselective preparation of triply isotope-labeled Ser, Cys, and Ala
• Preparation of β-amino acids from asymmetric hydrogenation of α-(aminomethyl)acrylates
• Asymmetric hydrogenation of a-primary and secondary amino ketones and asymmetric synthesis of (-)-arbutamine and (-)-denopamine

The Uses of (+)-1,2-Bis((2S,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium(l)tetrafluoroborate

(S,S)-Et-DUPHOS-Rh is a catalyst in the asymmetric preparation of B precursor of cryptophycin, and in the synthesis of constrained phenylalanine analogs.