CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Color/Form | CRYSTALS FROM PETROLEUM ETHER |
| Odor | PRACTICALLY ODORLESS |
| Melting Point | 105.5-107.5 |
| Solubility | 1000 mg/L (at 25 °C) |
| LogP | 3 |
| Stability/Shelf Life | LIGHT-SENSITIVE |
| pH | BETWEEN 7.6 & 8.6 (SATURATED SOLUTION) |
| Collision Cross Section | 166.7 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)] |
| Kovats Retention Index | 2020 2027 2027 2017 2010 2010 2020 2026.3 2020 2035 2020 |
| Other Experimental Properties | ODORLESS OR NEARLY SO & HAS BITTER TASTE; MELTS INDISTINCTLY & WITH DECOMP @ 285 °C /HYDROCHLORIDE/ |
COMPUTED DESCRIPTORS
| Molecular Weight | 266.4 g/mol |
|---|---|
| XLogP3 | 3.6 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 3 |
| Exact Mass | 266.178298710 g/mol |
| Monoisotopic Mass | 266.178298710 g/mol |
| Topological Polar Surface Area | 6.5 Ų |
| Heavy Atom Count | 20 |
| Formal Charge | 0 |
| Complexity | 253 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Cyclizine is an N-alkylpiperazine in which one nitrogen of the piperazine ring is substituted by a methyl group, while the other is substituted by a diphenylmethyl group. It has a role as an antiemetic, a cholinergic antagonist, a central nervous system depressant, a local anaesthetic and a H1-receptor antagonist.