CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Physostigmine is a white, odorless, microcrystalline powder. Used as a cholinergic (anticholinesterase) agent and as a veterinary medication. (EPA, 1998) |
|---|---|
| Color/Form | ORTHORHOMBIC SPHENOIDAL PRISMS OR CLUSTERS OF LEAFLETS FROM ETHER OR BENZENE |
| Odor | ODORLESS |
| Melting Point | 221 to 223 °F (EPA, 1998) |
| Solubility | 7760 mg/L |
| LogP | 1.58 |
| Stability/Shelf Life | SOLID & SOLNS TURN RED ON EXPOSURE TO HEAT, LIGHT, AIR, & ON CONTACT WITH TRACES OF METALS. |
| Optical Rotation | SPECIFIC OPTICAL ROTATION @ 17 °C/D= -76 DEG (CONCENTRATION BY VOLUME = 1.3 GIN 100 ML CHLOROFORM); @ 25 °C/D= -120 DEG (BENZENE) |
| Decomposition | When heated to decomposition it emits toxic fumes of oxides of nitrogen. |
| Dissociation Constants | 8.17 |
| Other Experimental Properties | HYGROSCOPIC |
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H300:Acute toxicity,oral H330:Acute toxicity,inhalation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P284:Wear respiratory protection. P320:Specific treatment is urgent (see … on this label). P330:Rinse mouth. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. |
COMPUTED DESCRIPTORS
| Molecular Weight | 275.35 g/mol |
|---|---|
| XLogP3 | 0.7 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 2 |
| Exact Mass | 275.16337692 g/mol |
| Monoisotopic Mass | 275.16337692 g/mol |
| Topological Polar Surface Area | 44.8 Ų |
| Heavy Atom Count | 20 |
| Formal Charge | 0 |
| Complexity | 403 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Physostigmine is a white, odorless, microcrystalline powder. Used as a cholinergic (anticholinesterase) agent and as a veterinary medication. (EPA, 1998)