CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Color/Form | Crystal from ethanol-methanol |
| Melting Point | 230-232 °C |
| Solubility | 7.00e-02 g/L |
| LogP | 2.9 |
| Stability/Shelf Life | Vindesine sulfate is most stable at pH 1.9. It may precipitate in a soln with a pH >6. ... Vindesine sulfate 20 ug/ml in dextrose 5% in water, Ringer's injection, lactate, or sodium chloride 0.9% underwent no degradation after 4 wk when frozen at -20 °C. /Vindesine sulfate/ |
| Optical Rotation | Optical rotation: +39.4 deg (c = 1.0 in methanol) |
| Dissociation Constants | pKa: 6.04, 7.67 |
COMPUTED DESCRIPTORS
| Molecular Weight | 753.9 g/mol |
|---|---|
| XLogP3 | 2.7 |
| Hydrogen Bond Donor Count | 5 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 7 |
| Exact Mass | 753.41014911 g/mol |
| Monoisotopic Mass | 753.41014911 g/mol |
| Topological Polar Surface Area | 165 Ų |
| Heavy Atom Count | 55 |
| Formal Charge | 0 |
| Complexity | 1570 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 9 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Vindesine is a vinca alkaloid, a methyl ester, an organic heterotetracyclic compound, an organic heteropentacyclic compound, a tertiary alcohol, a tertiary amino compound and a primary carboxamide. It has a role as an antineoplastic agent. It is functionally related to a vincaleukoblastine.