24584-09-6
Product Name:
Dexrazoxane
Formula:
C11H16N4O4
Synonyms:
(+)-(S)-4,4′-Propylenedi-2,6-piperazinedione;(S)-(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane;Cardioxane;Zinecard
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Color/Form | Crystals from aqueous methanol/ether |
| Melting Point | 191-197 °C |
| Solubility | Sparingly soluble |
| Vapor Pressure | 2.0X10-15 mm Hg at 25 °C /Estimated/ |
| LogP | -2.6 |
| Henry's Law Constant | Henry's law constant = 2.1X10-19 atm-cu m/mole at 25 °C /Estimated/ |
| Stability/Shelf Life | Reconstituted and diluted solutions are stable for 6 hours at controlled room temperature or under refrigeration, 2 to 8 degrees C (36 to 46 degrees F). |
| Optical Rotation | Specific optical rotation = +11.35 deg (c=5 in dimethylformamide) |
| Dissociation Constants | 2.1 |
| Other Experimental Properties | Hydroxyl radical reaction rate constant = 2.0X10-10 cu cm/molec-sec at 25 °C /Estimated/ |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
COMPUTED DESCRIPTORS
| Molecular Weight | 268.27 g/mol |
|---|---|
| XLogP3 | -1.4 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 3 |
| Exact Mass | 268.11715500 g/mol |
| Monoisotopic Mass | 268.11715500 g/mol |
| Topological Polar Surface Area | 98.8 Ų |
| Heavy Atom Count | 19 |
| Formal Charge | 0 |
| Complexity | 404 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
(+)-dexrazoxane is a razoxane. It has a role as a chelator, an antineoplastic agent, a cardiovascular drug and an immunosuppressive agent.