CHEMICAL AND PHYSICAL PROPERTIES
| Color/Form | Crystals from methanol or acetone |
|---|---|
| Melting Point | 104-406 °C |
| Solubility | In water, 1.4X10-2 mg/L @ 25 °C /Estimated/ |
| Vapor Pressure | 1.5X10-9 mm Hg @ 25 °C /Estimated/ |
| LogP | log Kow = 7.3 /Estimated/ |
| Henry's Law Constant | Henry's Law constant = 2.0X10-11 atm-cu m/mol @ 25 °C /Estimated/ |
| Other Experimental Properties | Easily oxidized by air and other oxidizing agents to desipramine and p-chlorbenzoic acid |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H413:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..… |
COMPUTED DESCRIPTORS
| Molecular Weight | 419.0 g/mol |
|---|---|
| XLogP3 | 6.8 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 7 |
| Exact Mass | 418.1811912 g/mol |
| Monoisotopic Mass | 418.1811912 g/mol |
| Topological Polar Surface Area | 23.6 Ų |
| Heavy Atom Count | 30 |
| Formal Charge | 0 |
| Complexity | 523 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Lofepramine is a dibenzoazepine, a member of monochlorobenzenes, a tertiary amino compound and an aromatic ketone. It has a role as an antidepressant.