ZT-12-037-01
- CAS NO.：2328073-61-4
- Empirical Formula: C21H31N5O2
- Molecular Weight: 385.5
- MDL number: MFCD32197197
- Update Date: 2025-12-03 18:03:33
What is ZT-12-037-01?
Biological Activity
ZT-12-037-01 is an ATP-competitive STK19 inhibitor with IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively. At a concentration of 1 μM, it is highly selective against a kinase library of 468 kinases.
in vitro
Treatment with ZT-12-037-01 could effectively inhibit NRAS phosphorylation. ZT-12-037-01 is an ATP-competitive inhibitor that potently inhibits melanocytic colony formation, proliferation and tumor formation driven by mutant NRAS-STK19. It's pro-apoptotic activity was significantly enhanced in cells expressing oncogenic NRAS.
in vivo
ZT-12-037-01 is a potent STK19 inhibitor with low toxicity in vivo. In the SK-MEL-2 xenograft model (carrying NRAS.
Properties of ZT-12-037-01
| storage temp. | 2-8°C(protect from light) |
| solubility | DMSO: 8.33 mg/mL (21.61 mM) |
| form | Solid |
| color | White to off-white |
Safety information for ZT-12-037-01
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for ZT-12-037-01
New Products
(E)-1-Ethoxyethene-2-boronic Acid Pinacol Ester 1,3-Diethyl-1,3-Diphenylurea 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile Methyl 2-methylquinoline-6-carboxylate 2,4-dihydroxybenzaldehyde 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile 1,3-Di Iodo Benzene Methyl 2-oxo-2,3-dihydrobenzo[d]oxazole-7-carboxylate 4-(2-Aminoethyl)-7-hydroxy-2H-chromoen-2-one 3-Hydroxy-4-nitrobromobenzene 2-Ethyl-1,4-diaminobenzene 2-Ethylhexyl 4-aminobenzoate Thio AcetamideRelated products of tetrahydrofuran
You may like
-
ZT-12-037-01 CAS 2328073-61-4View Details
2328073-61-4 -
MFCD22560726 98%View Details
MFCD22560726 -
3-Hydroxy-4-nitrobromobenzene 98%View Details
2768-84-0 -
4-(2-Aminoethyl)-7-hydroxy-2H-chromoen-2-one 98%View Details
1234064-08-4. -
2-Ethyl-1,4-diaminobenzene 98%View Details
MFCD19203885 -
2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile 98%View Details
-
Hot Sales:Thio AcetamideView Details
62-55-5 -
CosmoticsView Details
26218-04-2
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.