Zileuton (sodiuM)

Biological Activity

zileuton sodium is an inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes(ltb4, ltc4, ltd4 and lte4) formation with an ic50 value of 0.5μm [1].zileuton sodium has been reported to concentration-dependently inhibit the 5-lipoxygenase activity with an ic50 value of 0.5μm in rbl-1cell lysate. in addition, zileuton sodium has been found to be a potent inhibitor of ltb formation with an ic50 value of 0.6μm. furthermore, stimulated with a23187, zileuton sodium has shown a dose-dependent reduction in ltb4 and 5-hete generation in rat leukocyte with ic50 values of 0.38μm and 0.31μm, respectively. about 40-fold higher concentrations of zileuton sodium also reduced the production of pge2 with a ic50 of 16μm [1].

References

[1] carter gw1, young pr, albert dh, bouska j, dyer r, bell rl, summers jb, brooks dw. 5-lipoxygenase inhibitory activity of zileuton. j pharmacol exp ther. 1991 mar; 256(3):929-37.