(Z)-Guggulsterone
- CAS NO.：95975-55-6
- Empirical Formula: C21H28O2
- Molecular Weight: 312.45
- MDL number: MFCD01310757
- EINECS: 1308068-626-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-27 17:00:41
What is (Z)-Guggulsterone?
The Uses of (Z)-Guggulsterone
Guggulsterone is a broad spectrum steroid receptor ligand. Gum resin of Commiphora mukul marketed as an antihyperlipidemic drug.
What are the applications of Application
Guggulsterone is a broad spectrum steroid receptor ligand
Definition
ChEBI: Guggulsterone is a 3-hydroxy steroid. It has a role as an androgen.
Biological Activity
Broad spectrum steroid receptor ligand; binds with high affinity to mineralocorticoid receptors (K i = 39 nM) and lower affinity to progesterone, androgen and glucocorticoid receptors (K i values are 201, 240 and 224 nM respectively). Functions primarily as an antagonist of these receptors, with the exception of the progesterone receptor where it displays partial agonist effects. Also exerts hypolipidemic activity, likely via antagonism of the receptor for bile acids (farnesoid X receptor; FXR).
Properties of (Z)-Guggulsterone
| Boiling point: | 463.3±45.0 °C(Predicted) |
| Density | 1.10±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 5 mg/mL |
| form | powder |
| color | light yellow |
| CAS DataBase Reference | 95975-55-6(CAS DataBase Reference) |
Safety information for (Z)-Guggulsterone
Computed Descriptors for (Z)-Guggulsterone
(Z)-Guggulsterone manufacturer
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