YW1128

CAS NO.：2131223-64-6
Empirical Formula: C20H17N5O
Molecular Weight: 343.38
Update Date: 2026-01-05 11:31:08

What is YW1128?

Description

YW1128 is an inhibitor of Wnt/β-catenin signaling with an IC₅₀ value of 4.1 nM in a reporter assay. It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cells. YW1128 decreases lipid accumulation and the expression of gluconeogenic and lipogenic genes in Huh7 cells. It decreases the hepatic expression of Wnt target genes, improves glucose tolerance, and prevents body weight increases and hepatic lipid accumulation in mice fed a high-fat diet, but not mice fed normal chow, when administered at a dose of 40 mg/kg every other day for 11 weeks.

Properties of YW1128

storage temp.	Store at -20°C
solubility	DMF: 30mg/mL; DMSO: 30mg/mL; Ethanol: 30mg/mL; PBS (pH 7.2): 2mg/mL
form	A crystalline solid
color	White to off-white

Safety information for YW1128

Computed Descriptors for YW1128

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