XRK3F2

CAS NO.：2375193-43-2
Empirical Formula: C23H24ClF2NO3
Molecular Weight: 435.9
MDL number: MFCD31812777
Update Date: 2026-01-05 11:31:08

What is XRK3F2?

Biological Activity

XRK3F2 is a p62-ZZ inhibitor that blunts multiple myeloma (MM)-induced Runx2 inhibition in vitro and induces new bone formation and remodeling in the presence of tumors in vivo.

in vivo

In vivo, XRK3F2 induces new bone formation and remodeling in tumors. The half-life of it in mice was 10.3 hours. In bone with multiple myeloma, it induced significant local new bone formation, but not in mice not directly inoculated with multiple myeloma cells.

Properties of XRK3F2

storage temp.	Store at -20°C
solubility	DMSO : 150 mg/mL (344.12 mM);Water : 0.91 mg/mL (2.09 mM)
form	Solid
color	White to off-white

Safety information for XRK3F2

Signal word	Warning
Pictogram(s)	Health Hazard GHS08
GHS Hazard Statements	H320:Serious eye damage/eye irritation H372:Specific target organ toxicity, repeated exposure
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P270:Do not eat, drink or smoke when using this product. P314:Get medical advice/attention if you feel unwell. P403:Store in a well-ventilated place.

Computed Descriptors for XRK3F2

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